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== Matrix Metalloproteinase-1 (MMP-1) ==

Matrix Metalloproteinase-1 (MMP-1)is interstitial collagenase and fibroblast collagenase. The enzyme in humans is encoded by the MMP1 gene. Human Fibroblast Collagenase (MMP-1) was the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA [1].

Matrix Metalloproteinase-1 (MMP-1)is interstitial collagenase and fibroblast collagenase. The enzyme in humans is encoded by the MMP1 gene. Human Fibroblast Collagenase (MMP-1) was actually the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA [1].

~~Proteins~~ of ~~the matrix metalloproteinase~~ (~~MMP~~) family are involved in the ~~breakdown~~ of ~~extracellular matrix~~ in ~~normal physiological processes,~~ such as embryonic development, reproduction, and tissue remodeling~~, as well as~~ in disease processes, such as arthritis and metastasis~~. MMP-1, as with most MMP's, is secreted as inactive proproteins which is later activated when cleaved by extracellular proteases [2][3]~~.

MMP-1 belongs to a family of enzymes known as Matrix metalloproteinases (MMPs). These enzymes are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMP's are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis,host defense, embryonic development, reproduction, and tissue remodeling. MMP's are also involved in disease processes, such as arthritis and metastasis.

MMP's were first described in vertebrates in 1962 but have also been found in invertebrates and plants. They are distinguished from other endopeptidases by their dependence on metal ions as cofactors, their ability to degrade extracellular matrix, and their specific evolutionary DNA sequence. MMP's are secreted as inactive proproteins which is later activated when cleaved by extracellular proteases [2][3].

== Structure ==

Sandbox Reserved 468: Difference between revisions

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 == Matrix Metalloproteinase-1 (MMP-1) ==
-Matrix Metalloproteinase-1 (MMP-1)is interstitial collagenase and fibroblast collagenase. The enzyme in humans is encoded by the MMP1 gene. Human Fibroblast Collagenase (MMP-1) was the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA [1].
+Matrix Metalloproteinase-1 (MMP-1)is interstitial collagenase and fibroblast collagenase. The enzyme in humans is encoded by the MMP1 gene. Human Fibroblast Collagenase (MMP-1) was actually the first vertebrate collagenase both purified to homogeneity as a protein, and cloned as a cDNA [1].
-Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP-1, as with most MMP's, is secreted as inactive proproteins which is later activated when cleaved by extracellular proteases [2][3].
+MMP-1 belongs to a family of enzymes known as Matrix metalloproteinases (MMPs). These enzymes are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMP's are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis,host defense, embryonic development, reproduction, and tissue remodeling. MMP's are also involved in disease processes, such as arthritis and metastasis.
+MMP's were first described in vertebrates in 1962 but have also been found in invertebrates and plants. They are distinguished from other endopeptidases by their dependence on metal ions as cofactors, their ability to degrade extracellular matrix, and their specific evolutionary DNA sequence. MMP's are secreted as inactive proproteins which is later activated when cleaved by extracellular proteases [2][3].
 == Structure ==