Sandbox Reserved 468: Difference between revisions

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== Medical Implications ==

Research has shown that MMP-1 may have many medical implications. MMP-1 plays an important role in many physiologic processes such as development, tissue morphogenesis, wound repair and the remodeling of collagenous extracellular matrix. The enzyme is expressed by over 30 different cells. Collagen serves as a structural scaffold and a barrier between tissues, and thus collagen catabolism (collagenolysis) is required to be a tightly regulated process in normal physiology. In turn, the destruction or damage of collagen during pathological states plays a role in tumor growth and invasion, cartilage degradation, or atherosclerotic plaque formation and rupture [4].

Research has shown that MMP-1 may have many medical implications. MMP-1 plays an important role in many physiologic processes such as development, tissue morphogenesis, wound repair and the remodeling of collagenous extracellular matrix. The enzyme is expressed by over 30 different cells. Therefore, it is quite obvious that if this enzyme is not functioning properly then these processes will be affected, which could have little to no effect or have devastating effects. Remember that MMP-1 is a collagenase and the importance of collagen must not be overlooked. Collagen serves as a structural scaffold and a barrier between tissues, and thus collagen catabolism (collagenolysis) is required to be a tightly regulated process in normal physiology. In turn, the destruction or damage of collagen during pathological states plays a role in tumor growth and invasion, cartilage degradation, or atherosclerotic plaque formation and rupture. Thus, it becomes easy to see the importance of MMP-1 in terms of its medical implications [4].

This figure shows the different cells that MMPs are expressed in.

[[Image:mmp_cells.jpg]]

MMP-1 gene expression has also been shown to have implications with cancer treatment. MMP-1 can be used as a candidate marker that may be useful for identification of breast lesions that can develop into cancer [5].

MMP-1 gene expression has also been shown to have implications with cancer treatment. MMP-1 can be used as a candidate marker that may be useful for identification of breast lesions that can develop into cancer. As such, the medical implications of MMP-1 go beyond just what happens if the enzyme functions improperly but the enzyme, well rather the gene that encodes the enzyme, can also aid the diagnosis and subsequent treatment of breast cancer [5].

== References ==

Sandbox Reserved 468: Difference between revisions

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@@ Line 45: / Line 45: @@
 == Medical Implications ==
-Research has shown that MMP-1 may have many medical implications. MMP-1 plays an important role in many physiologic processes such as development, tissue morphogenesis, wound repair and the remodeling of collagenous extracellular matrix. The enzyme is expressed by over 30 different cells. Collagen serves as a structural scaffold and a barrier between tissues, and thus collagen catabolism (collagenolysis) is required to be a tightly regulated process in normal physiology. In turn, the destruction or damage of collagen during pathological states plays a role in tumor growth and invasion, cartilage degradation, or atherosclerotic plaque formation and rupture [4].
+Research has shown that MMP-1 may have many medical implications. MMP-1 plays an important role in many physiologic processes such as development, tissue morphogenesis, wound repair and the remodeling of collagenous extracellular matrix. The enzyme is expressed by over 30 different cells. Therefore, it is quite obvious that if this enzyme is not functioning properly then these processes will be affected, which could have little to no effect or have devastating effects. Remember that MMP-1 is a collagenase and the importance of collagen must not be overlooked. Collagen serves as a structural scaffold and a barrier between tissues, and thus collagen catabolism (collagenolysis) is required to be a tightly regulated process in normal physiology. In turn, the destruction or damage of collagen during pathological states plays a role in tumor growth and invasion, cartilage degradation, or atherosclerotic plaque formation and rupture. Thus, it becomes easy to see the importance of MMP-1 in terms of its medical implications [4].
 This figure shows the different cells that MMPs are expressed in.
 [[Image:mmp_cells.jpg]]
-MMP-1 gene expression has also been shown to have implications with cancer treatment. MMP-1 can be used as a candidate marker that may be useful for identification of breast lesions that can develop into cancer [5].
+MMP-1 gene expression has also been shown to have implications with cancer treatment. MMP-1 can be used as a candidate marker that may be useful for identification of breast lesions that can develop into cancer. As such, the medical implications of MMP-1 go beyond just what happens if the enzyme functions improperly but the enzyme, well rather the gene that encodes the enzyme, can also aid the diagnosis and subsequent treatment of breast cancer [5].
 == References ==