Sandbox Reserved 468: Difference between revisions
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In MMPs the catalytic domain is followed by a stretch of 15–65 amino acid residues referred to as the linker or the hinge region. The length of this region varies between MMPs and does not have a well-determined structure. This region is typically rich in proline residues. Interestingly, the replacement of those with alanine drastically reduced the collagenolytic activity of certain MMPs, which may indicate that the presence of the correct linker structure is important for collagenolysis [4]. | In MMPs the catalytic domain is followed by a stretch of 15–65 amino acid residues referred to as the linker or the hinge region. The length of this region varies between MMPs and does not have a well-determined structure. This region is typically rich in proline residues. Interestingly, the replacement of those with alanine drastically reduced the collagenolytic activity of certain MMPs, which may indicate that the presence of the correct linker structure is important for collagenolysis [4]. | ||
Here is a representation of the linker region. | |||
[[Image:Linker.jpg]] | [[Image:Linker.jpg]] | ||
