Sandbox Reserved 475: Difference between revisions
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== '''Structure''' == | == '''Structure''' == | ||
[[Image:Nicotinic Acetylcholine Receptor.jpg |left|alt=text|Caption]] | [[Image:Nicotinic Acetylcholine Receptor.jpg |left|alt=text|Caption]] | ||
<span style="font-size:110%"> | <span style="font-size:110%"> | ||
Nicotinic Acetylcholine Receptor is composed up five distinct subunits (shown in figure to left): α1, α2, β1, δ, and ε. The neurotransmitter acetylcholine | |||
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<span style="font-size:110%"> | |||
In vertebrates, nicotinic receptors are classified by their main sites of expression into two subtypes: muscle-type nicotinic receptors and neuronal-type nicotinic receptors. In the muscle-type receptors, found at the neuromuscular junction, receptors are either the embryonic form, composed of α1, β1, δ, and γ subunits in a 2:1:1:1 ratio, or the adult form composed of α1, β1, δ, and ε subunits in a 2:1:1:1 ratio.[1][2][3][7] The neuronal subtypes are various combinations of twelve different nicotinic receptor subunits: α2 through α10 and β2 through β4. In both muscle-type and neuronal-type receptors, the subunits are somewhat similar to one another, especially in the hydrophobic regions. | |||
</span> | </span> | ||
== '''Medical Applications''' == | == '''Medical Applications''' == | ||
== '''References''' == | == '''References''' == | ||