Sandbox Reserved 466: Difference between revisions

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	== Mechanism of Action ==		== Mechanism of Action ==
	Tetanus toxin binds to the neural cells through gangliosides and a second protein receptor. Once bound, they enter the cytosol via a vesicle membrane. Here, they attack and cleave the proteins that forms the synaptic vesicle fusion apparatus [Krishnamurthy et al., 2005]. The clostridial neurotoxins each have unique binding sites and substrate bond cleavage specificity. Tetanus toxin cleaves vesicle-associated membrane proteins.		Tetanus toxin binds to the neural cells through gangliosides and a second protein receptor. Once bound, they enter the cytosol via a vesicle membrane. Here, they attack and cleave the proteins that forms the synaptic vesicle fusion apparatus [Krishnamurthy et al., 2005]. The clostridial neurotoxins each have unique binding sites and substrate bond cleavage specificity. Tetanus toxin cleaves vesicle-associated membrane proteins. The VAMP protein is cleaved at the peptide bond Gln76-Phe77 requiring a amino-terminal extension of 22 residues and a peptide of 33-97 residues in length [Kirshnamurthy et al., 2005].

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