Sandbox Reserved 485: Difference between revisions
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The export of cargo into the cytoplasm typically involves RNA molecules that are synthesized in the nucleus but function in the cytoplasm. The receptor protein known as exportin binds to Ran-GTP within the nucleus to promote the recognition and binding of exportin to the nuclear export signals, NES, the is located on the RNA bound cargo protein. The exportin then mediates the transport of the complex through the nuclear pores | The export of cargo into the cytoplasm typically involves RNA molecules that are synthesized in the nucleus but function in the cytoplasm. The receptor protein known as exportin binds to Ran-GTP within the nucleus to promote the recognition and binding of exportin to the nuclear export signals, NES, the is located on the RNA bound cargo protein. The exportin then mediates the transport of the complex through the nuclear pores | ||
The key to the import and export of cargo material is dependent on the concentration of Ran-GTP. The concentration of Ran-GTP is maintained by guanine-nucleotide exchange factor, GEF, in the nucleus and a GTPase activating protein, GAP, in the cytosol. Cellular signals indicate the course of the Ran cycle and is especially significant while entering mitosis. | The key to the import and export of cargo material is dependent on the concentration of Ran-GTP. The concentration of Ran-GTP is maintained by guanine-nucleotide exchange factor, GEF, in the nucleus and a GTPase activating protein, GAP, in the cytosol. Cellular signals indicate the course of the Ran cycle and is especially significant while entering mitosis. | ||
[[Image:Ran cycle.jpg]] | [[Image:Ran cycle.jpg | thumb]] | ||
==Possible Applications== | ==Possible Applications== | ||
Ran also serves a variety of other functions such as mediating DNA synthesis and advancements through a cell cycle. Ran regulates these functions by directing the formation and organization of the microtubule complex. Ran-GTP promotes spindle assembly and the spindle fiber’s attachment to the chromosome. Ran is also involved in activating T cells and the reassembly of the nuclear envelope during mitosis. | Ran also serves a variety of other functions such as mediating DNA synthesis and advancements through a cell cycle. Ran regulates these functions by directing the formation and organization of the microtubule complex. Ran-GTP promotes spindle assembly and the spindle fiber’s attachment to the chromosome. Ran is also involved in activating T cells and the reassembly of the nuclear envelope during mitosis. | ||
