Sandbox Reserved 477: Difference between revisions
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Mechanism of Action | |||
The mechanism using GAPDH to convert glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate in the sixth step of glycolysis is a two step process. The first reaction is the oxidation of glyceraldehyde-3-phosphate at the 1st carbon position. At this position, an aldehyde is converted into a carboxylic acid while NAD+ is simultaneously reduced to NADH. This reaction is energetically favorable with a Gibb's free energy of -50kJ/mol. The energy released by the first reaction drives the second reaction. In the second reaction, a molecule of inorganic phosphate is transferred to the intermediate to form the final product of this reaction that has a high phosphoryl-transfer reaction, 1,3-bisphosphoglycerate. | The mechanism using GAPDH to convert glyceraldehyde-3-phosphate into 1,3-bisphosphoglycerate in the sixth step of glycolysis is a two step process. The first reaction is the oxidation of glyceraldehyde-3-phosphate at the 1st carbon position. At this position, an aldehyde is converted into a carboxylic acid while NAD+ is simultaneously reduced to NADH. This reaction is energetically favorable with a Gibb's free energy of -50kJ/mol. The energy released by the first reaction drives the second reaction. In the second reaction, a molecule of inorganic phosphate is transferred to the intermediate to form the final product of this reaction that has a high phosphoryl-transfer reaction, 1,3-bisphosphoglycerate. | ||
