Sandbox Reserved 486: Difference between revisions
From Proteopedia
Jump to navigationJump to search
| Line 28: | Line 28: | ||
*The T domain is found in fragment B and is the translocation portion of the protein. The structure is made up of three layers of α helices. The outer layer contains 3 helices that are rich in polar residues that allow for the molecule to maintain the T domain as well as keeping the toxin soluble in neutral pH. | *The T domain is found in fragment B and is the translocation portion of the protein. The structure is made up of three layers of α helices. The outer layer contains 3 helices that are rich in polar residues that allow for the molecule to maintain the T domain as well as keeping the toxin soluble in neutral pH. | ||
* | *Another domain in fragment B is domain R which has the <scene name='Sandbox_Reserved_486/Receptor_binding_site/1'>Receptor binding site</scene> for the protein. The domain consist mostly of β sheets and changes conformation when interacting with cell membranes. In the R domain both Lsy516 and Phe530 play a role in recognizing receptors on cell surfaces. | ||
<scene name='Sandbox_Reserved_486/Ligands/2'>Ligand</scene> | <scene name='Sandbox_Reserved_486/Ligands/2'>Ligand</scene> | ||
| Line 35: | Line 35: | ||
<scene name='Sandbox_Reserved_486/Secondary_structure/1'>Secondary Structure</scene> | <scene name='Sandbox_Reserved_486/Secondary_structure/1'>Secondary Structure</scene> | ||
== Mechanism == | == Mechanism == | ||
