User:Marvin O'Neal/OspC: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Irene Chen (talk | contribs) No edit summary |
Irene Chen (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_1ggq| PDB=1ggq | SCENE=Studio:G4SecL04/Initial_02/1 | {{STRUCTURE_1ggq| PDB=1ggq | SCENE=Studio:G4SecL04/Initial_02/1}} | ||
Lyme disease is a typical epidemic in northeastern and north central regions of the United States. It is also the most prevalent tick-borne disease which is caused by ''Borrelia burgdoferi'',a spirochete that is identified in ''Ixodes scapulars''. Humans infected with Lyme disease begin with unusal skin lesions (erythema chronicum migrans), which later develop into more severe neurological and cardiac symptoms | Lyme disease is a typical epidemic in northeastern and north central regions of the United States. It is also the most prevalent tick-borne disease which is caused by ''Borrelia burgdoferi'',a spirochete that is identified in ''Ixodes scapulars''. Humans infected with Lyme disease begin with unusal skin lesions (erythema chronicum migrans), which later develop into more severe neurological and cardiac symptoms | ||
<ref>PMID:7043737</ref>. If it is not completely treated, the causative agent of Lyme disease persists in human by interacting the surface-exposed ''B. burgdoferi'' proteins with the molecules of the host. Among 100 different lipoproteins present in its outer surface, the outer surface protein C (OspC) is one of its major host-induced antigens, but is inactive due to the immune response of mammalian host during its early age. The expression of OspC is dependent on temperature and it is induced when the tick migrates from guts to salivary gland during feeding period. OspC is highly polymorphic that based on alignment sequence, its genetic diversity at the OspC locus that can be categorized into 19 outer surface protein major groups (oMGs) ranged from type A to S. However, only four invasive allelic groups: A, B, I([[1f1m]]), and K, are responsible for causing human Lyme disease. | <ref>PMID:7043737</ref>. If it is not completely treated, the causative agent of Lyme disease persists in human by interacting the surface-exposed ''B. burgdoferi'' proteins with the molecules of the host. Among 100 different lipoproteins present in its outer surface, the outer surface protein C (OspC) is one of its major host-induced antigens, but is inactive due to the immune response of mammalian host during its early age. The expression of OspC is dependent on temperature and it is induced when the tick migrates from guts to salivary gland during feeding period. OspC is highly polymorphic that based on alignment sequence, its genetic diversity at the OspC locus that can be categorized into 19 outer surface protein major groups (oMGs) ranged from type A to S. However, only four invasive allelic groups: A, B, I([[1f1m]]), and K, are responsible for causing human Lyme disease. | ||
| Line 19: | Line 19: | ||
==Primary and Secondary structure of OspC== | ==Primary and Secondary structure of OspC== | ||
<Structure load='1ggq' size='300' frame='true' align='left' caption=' | <Structure load='1ggq' size='300' frame='true' align='left' caption='' scene='Studio:G4SecL04/Dimer_with_mg/1'/> | ||
The model presented is B31 strain (residues 38-201), which is also known as oMG A. This is one of four invasive oMGs that are responsible for systematic Lyme disease. In crystal structure, OspC exists as a | The model presented is B31 strain (residues 38-201), which is also known as oMG A. This is one of four invasive oMGs that are responsible for systematic Lyme disease. In crystal structure, OspC exists as a | ||
<scene name='Studio:G4SecL04/Regular_dimer/1' target='1'>dimer</scene> with the coordination of divalent ion, which is modeled as a magnesium ion. Each subunit is predominantly helical, consisting of five parallel | <scene name='Studio:G4SecL04/Regular_dimer/1' target='1'>dimer</scene> with the coordination of divalent ion, which is modeled as a magnesium ion. Each subunit is predominantly helical, consisting of five parallel | ||
<scene name='Studio:G4SecL04/Helix_blue_in_ribbon/1' target=' | <scene name='Studio:G4SecL04/Helix_blue_in_ribbon/1' target='0'> α-helices </scene> | ||
, two short antiparallel | , two short antiparallel | ||
<scene name='Studio:G4SecL04/Sheet_yellow_in_ribbon/ | <scene name='Studio:G4SecL04/Sheet_yellow_in_ribbon/1'> β-sheets</scene> | ||
and six | and six | ||
<scene name='Studio:G4SecL04/Random_coils/2' target='1'>random coils</scene> | <scene name='Studio:G4SecL04/Random_coils/2' target='1'>random coils</scene> | ||
