User:Marvin O'Neal/OspA: Difference between revisions
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<h3>Other Speculations about OspA's role in Lyme Disease</h3> | |||
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Borrelia have been shown to adhere to murine neural and glial cell lines using OspA. This adherence can be cytotoxic, due to OspA inducing apopotosis and astrogliosis.The borrelia spirochete is able to hide in certain areas of the body, specifically the extracellular matrix. This helps the spirochete survive by hiding from leukocytes circulating in the bloodstream. It is speculated that because OspA can also rapidly bind to plasminogen, and the plasminogen becomes activated plasmin that can degrade the extracellular matrix, borrelia could be using this to help invade the extracellular matrix. However there are also other possible explanations that do not involve OspA. Borrelia lead to local upregulation of the matrix metalloproteinase-9, which caues the digestion of the surrounding extracellular matrix. | |||
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<h2>OspA Vaccination</h2> | <h2>OspA Vaccination</h2> | ||
