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Matrix Metalloproteinase-1 (MMP-1)is a collagenase made up of two monomers. Collagenases are enzymes that break down the bonds in collagen. MMP-1 in humans is encoded by the MMP1 gene. Interestingly, MMP-1 was actually the first vertebrate collagenase that was both purified as a protein and cloned as cDNA [1].

Matrix Metalloproteinase-1 (MMP-1)is a collagenase made up of two monomers. Collagenases are enzymes that break down the bonds in collagen [1]. MMP-1 in humans is encoded by the MMP1 gene. Interestingly, MMP-1 was actually the first vertebrate collagenase that was both purified as a protein and cloned as cDNA [1].

MMP-1 belongs to a family of enzymes known as Matrix metalloproteinases (MMPs). These enzymes are known as zinc-dependent because of the zinc ions found in their catalytic sites. The MMPs belong to a larger family of proteins known as the metzincin superfamily. MMPs can degrade all kinds of extracellular matrix proteins as well as a number of other bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play an important role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis,host defense, embryonic development, reproduction, and tissue remodeling. MMPs are also involved in disease processes, such as arthritis and metastasis [5].

MMP-1 belongs to a family of enzymes known as Matrix metalloproteinases (MMPs). These enzymes are known as zinc-dependent because of the zinc ions found in their catalytic sites. The MMPs belong to a larger family of proteins known as the metzincin superfamily. MMPs can degrade all kinds of extracellular matrix proteins as well as a number of other bioactive molecules [5]. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play an important role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis,host defense, embryonic development, reproduction, and tissue remodeling. MMPs are also involved in disease processes, such as arthritis and metastasis [5].

This image shows the entire MMP family.

Sandbox Reserved 468: Difference between revisions

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 <Structure load='2clt' size='500' frame='true' align='right' caption='Matrix Metalloproteinase-1' scene='Insert optional scene name here' />
-Matrix Metalloproteinase-1 (MMP-1)is a collagenase made up of two monomers. Collagenases are enzymes that break down the bonds in collagen. MMP-1 in humans is encoded by the MMP1 gene. Interestingly, MMP-1 was actually the first vertebrate collagenase that was both purified as a protein and cloned as cDNA [1].
+Matrix Metalloproteinase-1 (MMP-1)is a collagenase made up of two monomers. Collagenases are enzymes that break down the bonds in collagen [1]. MMP-1 in humans is encoded by the MMP1 gene. Interestingly, MMP-1 was actually the first vertebrate collagenase that was both purified as a protein and cloned as cDNA [1].
-MMP-1 belongs to a family of enzymes known as Matrix metalloproteinases (MMPs). These enzymes are known as zinc-dependent because of the zinc ions found in their catalytic sites. The MMPs belong to a larger family of proteins known as the metzincin superfamily. MMPs can degrade all kinds of extracellular matrix proteins as well as a number of other bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play an important role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis,host defense, embryonic development, reproduction, and tissue remodeling. MMPs are also involved in disease processes, such as arthritis and metastasis [5].
+MMP-1 belongs to a family of enzymes known as Matrix metalloproteinases (MMPs). These enzymes are known as zinc-dependent because of the zinc ions found in their catalytic sites. The MMPs belong to a larger family of proteins known as the metzincin superfamily. MMPs can degrade all kinds of extracellular matrix proteins as well as a number of other bioactive molecules [5]. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play an important role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis,host defense, embryonic development, reproduction, and tissue remodeling. MMPs are also involved in disease processes, such as arthritis and metastasis [5].
 This image shows the entire MMP family.