Sandbox Reserved 479: Difference between revisions
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==Structure== | ==Structure== | ||
Myosin is a 520 kDa hexamer, or a '''hexa-oligomer''' (6 subunit) structure. It is comprised of two heavy chains (weighing 220 kDa each) and 4 light chains (weighing 20 kDa each).<ref name="CHEM43">[http://www.cs.stedwards.edu/chem/Chemistry/CHEM43/CHEM43/Myosin/STRUCT~1.HTM]</ref> The hexamer's 2 identical heavy chains connected via the coiled coil structure, and each containing a regulatory and essential light chain (total of 4). The 2-D structure below of myosin II shows 7 stranded <scene name='Sandbox_Reserved_479/2mys_beta_sheet/2'>beta sheet</scene> (Jmol) and the ATP-binding site between the middle and N-terminal of the protein. The C-terminal contains the light chains (regulatory domain) and acts as the lever arm to enhance the converter domain's rotational movements.<ref name="sampath">[http://www.sampath.koppole.com/research.htm]</ref> | Myosin is a 520 kDa hexamer, or a '''hexa-oligomer''' (6 subunit) structure. It is comprised of two heavy chains (weighing 220 kDa each) and 4 light chains (weighing 20 kDa each).<ref name="CHEM43">[http://www.cs.stedwards.edu/chem/Chemistry/CHEM43/CHEM43/Myosin/STRUCT~1.HTM]</ref> The hexamer's 2 identical heavy chains connected via the coiled coil structure, and each containing a regulatory and essential light chain (total of 4). The 2-D structure below of myosin II head shows 7 stranded <scene name='Sandbox_Reserved_479/2mys_beta_sheet/2'>beta sheet</scene> (Jmol) and the ATP-binding site between the middle and N-terminal of the protein. The C-terminal contains the light chains (regulatory domain) and acts as the lever arm to enhance the converter domain's rotational movements.<ref name="sampath">[http://www.sampath.koppole.com/research.htm]</ref> | ||
[[Image:Mds1.png]] | [[Image:Mds1.png]] | ||
