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====X-Ray Crystallography and Scattering====

It was not until recently that crystal structures could be used to analyze myosin and it's role in the actinomysin chemomechanical cycle. X-ray diffraction studies have been conducted on whole muscles and muscle fibers to learn how structural changes promote and facilitate motor activity. Modern synchrotron radiation sources allow us to study myosin at the molecular level under near-physiological conditions. Muscle cells exhibit low scattering power in X-ray images, however, so a clear crystalline structure cannot not form. A flat detector is needed because reflections are concentrated in the low angle regions. Snychrotron radiation generates a monochromatic X-ray breams of diameter 0.2-0.3 mm, similar to that of the muscle fiber, and making high resolution images and video of a single muscle cell possible via x-ray scattering patterns.<ref name="Koubassova">PMID: 22339600</ref>

It was not until recently that crystal structures could be used to analyze myosin and it's role in the actinomysin chemomechanical cycle. X-ray diffraction studies have been conducted on whole muscles and muscle fibers to learn how structural changes promote and facilitate motor activity. Modern synchrotron radiation sources allow us to study myosin at the molecular level under near-physiological conditions. Muscle cells exhibit low scattering power in X-ray images, however, so a clear crystalline structure cannot not form. A flat detector is needed because reflections are concentrated in the low angle regions. Snychrotron radiation generates a monochromatic X-ray breams of diameter 0.2-0.3 mm, similar to that of the muscle fiber, and making high resolution images and video of a single muscle cell possible via x-ray scattering patterns. New technology using snychrotron radiation and 2 dimensional detectors will allow researchers to gain even more insight into the structure of myosin and it's interaction with actin in unique time and spatial resolution.<ref name="Koubassova">PMID: 22339600</ref>

==Interaction with Actin==

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 ====X-Ray Crystallography and Scattering====
-It was not until recently that crystal structures could be used to analyze myosin and it's role in the actinomysin chemomechanical cycle.  X-ray diffraction studies have been conducted on whole muscles and muscle fibers to learn how structural changes promote and facilitate motor activity.  Modern synchrotron radiation sources allow us to study myosin at the molecular level under near-physiological conditions.  Muscle cells exhibit low scattering power in X-ray images, however, so a clear crystalline structure cannot not form.  A flat detector is needed because reflections are concentrated in the low angle regions.  Snychrotron radiation generates a monochromatic X-ray breams of diameter 0.2-0.3 mm, similar to that of the muscle fiber, and making high resolution images and video of a single muscle cell possible via x-ray scattering patterns.<ref name="Koubassova">PMID: 22339600</ref>
+It was not until recently that crystal structures could be used to analyze myosin and it's role in the actinomysin chemomechanical cycle.  X-ray diffraction studies have been conducted on whole muscles and muscle fibers to learn how structural changes promote and facilitate motor activity.  Modern synchrotron radiation sources allow us to study myosin at the molecular level under near-physiological conditions.  Muscle cells exhibit low scattering power in X-ray images, however, so a clear crystalline structure cannot not form.  A flat detector is needed because reflections are concentrated in the low angle regions.  Snychrotron radiation generates a monochromatic X-ray breams of diameter 0.2-0.3 mm, similar to that of the muscle fiber, and making high resolution images and video of a single muscle cell possible via x-ray scattering patterns.  New technology using snychrotron radiation and 2 dimensional detectors will allow researchers to gain even more insight into the structure of myosin and it's interaction with actin in unique time and spatial resolution.<ref name="Koubassova">PMID: 22339600</ref>
 ==Interaction with Actin==