Sandbox Reserved 452: Difference between revisions

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== Mechanism ==

Most of the biological functions that c-myc performs involves herterodimerization with Max. C-Myc primary function is activating the transcription of genes involved in cell proliferation, growth, and metabolism by binding to the DNA sequence CAGTG, also known as the Enhancer box, when it has dimerized with Max. Many studies have shown that without dimerizing to Max, c-Myc would not be able to bind to DNA, which makes thier interaction important to cellular function<ref>PMID:1501888~~</ref><ref>PMID:7577944~~</ref><ref>PMID:7577944</ref>. When c-Myc/Max form a herterodimer and bind DNA transcription becomes activated. When Myc-Max are bound this allows for proteins involved in transcription to bind like, TBP, TBIIE, TRRAP, etc. In a normal cell c-myc is very regulated and expresses little c-myc when the cell is resting. When cells becomes stimulated by growth factors c-myc is drastically increased. Over expression of c-myc in a normal cells results in apoptosis so that the organism is protected from abnormal cell growth. In abnormal cell when the c-myc gene is over expressed leads to cancer.

Most of the biological functions that c-myc performs involves herterodimerization with Max. C-Myc primary function is activating the transcription of genes involved in cell proliferation, growth, and metabolism by binding to the DNA sequence CAGTG, also known as the Enhancer box, when it has dimerized with Max. Many studies have shown that without dimerizing to Max, c-Myc would not be able to bind to DNA, which makes thier interaction important to cellular function<ref>PMID:1501888</ref><ref>PMID:7577944</ref>. When c-Myc/Max form a herterodimer and bind DNA transcription becomes activated. When Myc-Max are bound this allows for proteins involved in transcription to bind like, TBP, TBIIE, TRRAP, etc. In a normal cell c-myc is very regulated and expresses little c-myc when the cell is resting. When cells becomes stimulated by growth factors c-myc is drastically increased. Over expression of c-myc in a normal cells results in apoptosis so that the organism is protected from abnormal cell growth. In abnormal cell when the c-myc gene is over expressed leads to cancer.

== Medical Uses ==

Sandbox Reserved 452: Difference between revisions

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 == Mechanism ==
-Most of the biological functions that c-myc performs involves herterodimerization with Max. C-Myc primary function is activating the transcription of genes involved in cell proliferation, growth, and metabolism by binding to the DNA sequence CAGTG, also known as the Enhancer box, when it has dimerized with Max. Many studies have shown that without dimerizing to Max, c-Myc would not be able to bind to DNA, which makes thier interaction important to cellular function<ref>PMID:1501888</ref><ref>PMID:7577944</ref><ref>PMID:7577944</ref>. When c-Myc/Max form a herterodimer and bind DNA transcription becomes activated. When Myc-Max are bound this allows for proteins involved in transcription to bind like, TBP, TBIIE, TRRAP, etc. In a normal cell c-myc is very regulated and expresses little c-myc when the cell is resting. When cells becomes stimulated by growth factors c-myc is drastically increased. Over expression of c-myc in a normal cells results in apoptosis so that the organism is protected from abnormal cell growth. In abnormal cell when the c-myc gene is over expressed leads to cancer.
+Most of the biological functions that c-myc performs involves herterodimerization with Max. C-Myc primary function is activating the transcription of genes involved in cell proliferation, growth, and metabolism by binding to the DNA sequence CAGTG, also known as the Enhancer box, when it has dimerized with Max. Many studies have shown that without dimerizing to Max, c-Myc would not be able to bind to DNA, which makes thier interaction important to cellular function<ref>PMID:1501888</ref><ref>PMID:7577944</ref>. When c-Myc/Max form a herterodimer and bind DNA transcription becomes activated. When Myc-Max are bound this allows for proteins involved in transcription to bind like, TBP, TBIIE, TRRAP, etc. In a normal cell c-myc is very regulated and expresses little c-myc when the cell is resting. When cells becomes stimulated by growth factors c-myc is drastically increased. Over expression of c-myc in a normal cells results in apoptosis so that the organism is protected from abnormal cell growth. In abnormal cell when the c-myc gene is over expressed leads to cancer.
 == Medical Uses  ==