Sandbox Reserved 492: Difference between revisions
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Cholix also serves several valuable purposes in Biological research. Dr. Pierre-Hervé Luppi and his laboratory recently discovered a new "tracing" method using cholera-toxin instead of the previously used classical molecules such as Horse Radish Peroxidase (HRP). In contrast to HRP, which is '''passively''' taken up by neurons, cholera-toxin (as we discussed previously) binds specifically to surface receptors of neurons and is can be '''actively''' taken up and transported by the axons. <ref> [6] Pierre-Hervé Luppi. "The Discovery of Cholera-Toxin as a Powerful Neuroanatomical Tool". Retrieved 2011-03-23. </ref> This phenomenon helps enhance the sensitivity of cholera-toxin as a tracer, for studies dealing with neural function and the diseases known to affect it. [[Image:P34.png]] ''Structure of '''PJ34''''' | Cholix also serves several valuable purposes in Biological research. Dr. Pierre-Hervé Luppi and his laboratory recently discovered a new "tracing" method using cholera-toxin instead of the previously used classical molecules such as Horse Radish Peroxidase (HRP). In contrast to HRP, which is '''passively''' taken up by neurons, cholera-toxin (as we discussed previously) binds specifically to surface receptors of neurons and is can be '''actively''' taken up and transported by the axons. <ref> [6] Pierre-Hervé Luppi. "The Discovery of Cholera-Toxin as a Powerful Neuroanatomical Tool". Retrieved 2011-03-23. </ref> This phenomenon helps enhance the sensitivity of cholera-toxin as a tracer, for studies dealing with neural function and the diseases known to affect it. [[Image:P34.png]] ''Structure of '''PJ34''''' | ||
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As a result, aspirations for future research being done on Cholera Toxin today, coincide with a current "hot topic" within the science community and the entre World: '''Stem Cell Research.''' There have been some recent findings indicating that the protein may be capable of interacting - regulation on the genetic level - some key factors in Neural Stem Cell '''(NSC)''' regeneration and differentiation. Known as Tie2, a membrane receptor, and Hes3 a transcription factor, these two indicators have been shown to directly interact with the Cholix Toxin. Moreover, there are even some implications that the protein, when combined with specific medium, boosted Stem Cell culture growth.<ref>[7]Androutsellis-Theotokis, Andreas, Stuart Walbridge, Deric M. Park, Russel R. Lonser, and Ronald D. McKay. “Cholera Toxin Regulates a Signaling Pathway Critical for the Expansion of Neural Stem Cell Cultures from the Fetal and Adult Rodent Brains.” PLoS ONE 5, (2010)</ref> Thus, we see that apart from its potential to cause human illness, CX also poses | |||
As a result, aspirations for future research being done on Cholera Toxin today, coincide with a current "hot topic" within the science community and the entre World: '''Stem Cell Research.''' There have been some recent findings indicating that the protein may be capable of interacting - regulation on the genetic level - some key factors in Neural Stem Cell '''(NSC)''' regeneration and differentiation. Known as Tie2, a membrane receptor, and Hes3 a transcription factor, these two indicators have been shown to directly interact with the Cholix Toxin. Moreover, there are even some implications that the protein, when combined with specific medium, boosted Stem Cell culture growth.<ref>[7]Androutsellis-Theotokis, Andreas, Stuart Walbridge, Deric M. Park, Russel R. Lonser, and Ronald D. McKay. “Cholera Toxin Regulates a Signaling Pathway Critical for the Expansion of Neural Stem Cell Cultures from the Fetal and Adult Rodent Brains.” PLoS ONE 5, (2010)</ref> Thus, we see that apart from its potential to cause human illness, CX also poses a solution to cancer and other related diseases. [[Image:NSC.jpeg]] | |||
==References == | ==References == | ||
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