Sandbox Reserved 474: Difference between revisions

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== Biological Implications ==

It is known that CRP belongs to a highly conserved pentraxin class that is responsible for innate immunity and it aids in the prevention of developing an autoimmunity <ref> author,title </ref> ~~Complexed or aggregated CRP activates complent, with pro-inflammatory effects~~. For instance, a direct correlation has been made between increased levels of CRP to complications of atherosslerosis which may include a mycardial infarction. In addition, CRP has the ability to predict future outcomes as a result of the infarction. Furthermore, it was discovered that CRP ~~actually~~

It is known that CRP belongs to a highly conserved pentraxin class that is responsible for innate immunity and it aids in the prevention of developing an autoimmunity <ref> author,title </ref>. For instance, a direct correlation has been made between increased levels of CRP to complications of atherosslerosis which may include a mycardial infarction. In addition, CRP has the ability to predict future outcomes as a result of the infarction. Furthermore, it was discovered that CRP deposits itself within the infarcted tissues and it activates complement [1]. This effect was presumed to promote both pro and anti effects of CRP, which leaves it open as a future drug target [1].

One other biological effect/function of CRP includes CRP's unique ability to identify pathogens to server as the hosts' first line of defense.

~~Some of the~~ biological ~~effects~~/~~functions~~ of CRP ~~include:~~ CRP's unique ability to ~~only bind~~ to ~~phosphocholine ligands~~ of ~~either damaged or apoptotic cells~~. Additionally, CRP can bind to other ligands such as phosphoethanolamine, chromatin, histones, fibronectin, small nuclear ribonucleoproteins, laminin, and polycations. CRP also contains pleiotropic effects which produce both pro and anti-inflammatory responses.

== References ==

Sandbox Reserved 474: Difference between revisions

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 == Biological Implications ==
-It is known that CRP belongs to a highly conserved pentraxin class that is responsible for innate immunity and it aids in the prevention of developing an autoimmunity <ref> author,title </ref>  Complexed or aggregated CRP activates complent, with pro-inflammatory effects.  For instance, a direct correlation has been made between increased levels of CRP to complications of atherosslerosis which may include a mycardial infarction.  In addition, CRP has the ability to predict future outcomes as a result of the infarction.  Furthermore, it was discovered that CRP actually
+It is known that CRP belongs to a highly conserved pentraxin class that is responsible for innate immunity and it aids in the prevention of developing an autoimmunity <ref> author,title </ref>.  For instance, a direct correlation has been made between increased levels of CRP to complications of atherosslerosis which may include a mycardial infarction.  In addition, CRP has the ability to predict future outcomes as a result of the infarction.  Furthermore, it was discovered that CRP deposits itself within the infarcted tissues and it activates complement [1].  This effect was presumed to promote both pro and anti effects of CRP, which leaves it open as a future drug target [1].
+One other biological effect/function of CRP includes CRP's unique ability to identify pathogens to server as the hosts' first line of defense.
-Some of the biological effects/functions of CRP include: CRP's unique ability to only bind to phosphocholine ligands of either damaged or apoptotic cells.  Additionally, CRP can bind to other ligands such as phosphoethanolamine, chromatin, histones, fibronectin, small nuclear ribonucleoproteins, laminin, and polycations.  CRP also contains pleiotropic effects which produce both pro and anti-inflammatory responses.
 == References ==
 <references/>