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Matrix Metalloproteinase-1 (MMP-1)is a collagenase made up of two monomers. Collagenases are enzymes that break down the bonds in collagen <ref name="ncbi">http://www.ncbi.nlm.nih.gov/gene/4312</ref>. MMP-1 in humans is encoded by the MMP1 gene. Interestingly, MMP-1 was actually the first vertebrate collagenase that was both purified as a protein and cloned as cDNA <ref name="ncbi">http://www.ncbi.nlm.nih.gov/gene/4312</ref>. | Matrix Metalloproteinase-1 (MMP-1)is a collagenase made up of two monomers. Collagenases are enzymes that break down the bonds in collagen <ref name="ncbi">http://www.ncbi.nlm.nih.gov/gene/4312</ref>. MMP-1 in humans is encoded by the MMP1 gene. Interestingly, MMP-1 was actually the first vertebrate collagenase that was both purified as a protein and cloned as cDNA <ref name="ncbi">http://www.ncbi.nlm.nih.gov/gene/4312</ref>. | ||
MMP-1 belongs to a family of enzymes known as Matrix metalloproteinases (MMPs). These enzymes are known as zinc-dependent because of the zinc ions found in their catalytic sites. The MMPs belong to a larger family of proteins known as the metzincin superfamily. MMPs can degrade all kinds of extracellular matrix proteins as well as a number of other bioactive molecules | MMP-1 belongs to a family of enzymes known as Matrix metalloproteinases (MMPs). These enzymes are known as zinc-dependent because of the zinc ions found in their catalytic sites. The MMPs belong to a larger family of proteins known as the metzincin superfamily. MMPs can degrade all kinds of extracellular matrix proteins as well as a number of other bioactive molecules <ref name="nagase">Nagase, H. (2006). Structure and function of matrix metalloproteinases and timps. Cardiovascular Research, 69(3), 562-573. Retrieved from http://cardiovascres.oxfordjournals.org/content/69/3/562.full</ref>. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play an important role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis,host defense, embryonic development, reproduction, and tissue remodeling. MMPs are also involved in disease processes, such as arthritis and metastasis <ref name="nagase">Nagase, H. (2006). Structure and function of matrix metalloproteinases and timps. Cardiovascular Research, 69(3), 562-573. Retrieved from http://cardiovascres.oxfordjournals.org/content/69/3/562.full</ref>. | ||
This image shows the entire MMP family. | This image shows the entire MMP family. | ||
