1rcb: Difference between revisions
New page: left|200px<br /> <applet load="1rcb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rcb, resolution 2.25Å" /> '''CRYSTAL STRUCTURE O... |
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'''CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION'''<br /> | '''CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1RCB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1RCB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RCB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: cytokine]] | [[Category: cytokine]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:48:09 2008'' | ||
Revision as of 14:48, 15 February 2008
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CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION
Overview
The crystal structure of human recombinant interleukin-4 (IL-4) has been, solved by multiple isomorphous replacement, and refined to an R factor of, 0.218 at 2.25 A resolution. The molecule is a left-handed four-helix, bundle with a short stretch of beta sheet. The structure bears close, resemblance to other cytokines such as granulocyte-macrophage colony, stimulating factor (GM-CSF). Although no sequence similarity of IL-4 to, GM-CSF and other related cytokines has been previously postulated, structure-based alignment of IL-4 and GM-CSF revealed that the core of the, molecules, including large parts of all four helices and extending over, half of the molecule, has 30% sequence identity. This may have identified, regions which are not only important to maintain structure, but could also, play a role in receptor binding.
Disease
Known diseases associated with this structure: AIDS, slow progression to OMIM:[147781], Atopy, susceptibility to OMIM:[147781]
About this Structure
1RCB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human recombinant interleukin-4 at 2.25 A resolution., Wlodawer A, Pavlovsky A, Gustchina A, FEBS Lett. 1992 Aug 31;309(1):59-64. PMID:1511746
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