Sandbox Reserved 498: Difference between revisions

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Sumoylation results in modification of a protein for stability and not degradation even though its pathway mirrors that of the ubiquitin pathway.<ref name="Filip"/>

[[RanGAP1]] becomes a SUMO conjugate because the modification is needed for nucleocytplasmic transport and association with RanBP2 at the nuclear pore complex.<ref name="Victor"/><ref name="Lin"/>

RanGAP1 becomes a SUMO conjugate because the modification is needed for nucleocytplasmic transport and association with RanBP2 at the nuclear pore complex.<ref name="Victor"/><ref name="Lin"/>

[[PML]], PML-RAR, and SP100 are conjugated and targeted to the nucleus, to subnuclear structures, or to centromere segregation.<ref name="Victor"/><ref name="Lin"/>

PML, PML-RAR, and SP100 are conjugated and targeted to the nucleus, to subnuclear structures, or to centromere segregation.<ref name="Victor"/><ref name="Lin"/>

Research into why SUMO conjugation occurs, beyond regulation of cellular processes, suggests cellular stress activates an intracellular signal. SUMO proteins are found mostly unconjugated. If there is environmental stress then concentration of SUMO-conjugates increases.

<ref name="Courey">Courey, A.J. "Role of Sumo-conjugation in development." Department of Chemistry & Biochemistry, UCLA ['''http://www.biochemistry.ucla.edu/biochem/Faculty/Courey/researchB.html'''http://www.biochemistry.ucla.edu/biochem/Faculty/Courey/researchB.html]</ref>

Ubc9 is involved in degradation of cell cycle proteins. M-phase cyclin [[Clb5]], S-phase cyclin [[Clb2]], and G1 cyclins [[Cln1]] and [[Cln2]] are degraded for cell cycle regulation.<ref name="Tong"/>

Ubc9 is involved in degradation of cell cycle proteins. M-phase cyclin Clb5, S-phase cyclin Clb2, and G1 cyclins Cln1 and Cln2 are degraded for cell cycle regulation.<ref name="Tong"/>

'''Substrates'''

Sandbox Reserved 498: Difference between revisions

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@@ Line 43: / Line 43: @@
 Sumoylation results in modification of a protein for stability and not degradation even though its pathway mirrors that of the ubiquitin pathway.<ref name="Filip"/>
-[[RanGAP1]] becomes a SUMO conjugate because the modification is needed for nucleocytplasmic transport and association with RanBP2 at the nuclear pore complex.<ref name="Victor"/><ref name="Lin"/>
+RanGAP1 becomes a SUMO conjugate because the modification is needed for nucleocytplasmic transport and association with RanBP2 at the nuclear pore complex.<ref name="Victor"/><ref name="Lin"/>
-[[PML]], PML-RAR, and SP100 are conjugated and targeted to the nucleus, to subnuclear structures, or to centromere segregation.<ref name="Victor"/><ref name="Lin"/>
+PML, PML-RAR, and SP100 are conjugated and targeted to the nucleus, to subnuclear structures, or to centromere segregation.<ref name="Victor"/><ref name="Lin"/>
 Research into why SUMO conjugation occurs, beyond regulation of cellular processes, suggests cellular stress activates an intracellular signal. SUMO proteins are found mostly unconjugated. If there is environmental stress then concentration of SUMO-conjugates increases.
 <ref name="Courey">Courey, A.J. "Role of Sumo-conjugation in development." Department of Chemistry & Biochemistry, UCLA ['''http://www.biochemistry.ucla.edu/biochem/Faculty/Courey/researchB.html'''http://www.biochemistry.ucla.edu/biochem/Faculty/Courey/researchB.html]</ref>
-Ubc9 is involved in degradation of cell cycle proteins.  M-phase cyclin [[Clb5]], S-phase cyclin [[Clb2]], and G1 cyclins [[Cln1]] and [[Cln2]] are degraded for cell cycle regulation.<ref name="Tong"/>
+Ubc9 is involved in degradation of cell cycle proteins.  M-phase cyclin Clb5, S-phase cyclin Clb2, and G1 cyclins Cln1 and Cln2 are degraded for cell cycle regulation.<ref name="Tong"/>
 '''Substrates'''