Large T Antigen: Difference between revisions
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=== Introduction === | === Introduction === | ||
The '''SV40 large tumor antigen''' is a multifunctional regulatory protein encoded by Simian Virus 40. It is classified under the AAA+ family of helicases <ref name="A">PMID:8946857</ref>. | The '''SV40 large tumor antigen''' is a multifunctional regulatory protein encoded by Simian Virus 40. It is classified under the AAA+ family of helicases <ref name="A">PMID:8946857</ref>. The protein is responsible for initiation of viral DNA replication, regulation of viral transcription and transformation of the host cell to promote viral infectivity. Large T-antigen is an early gene product of SV40 and is produced via differential mRNA splicing. | ||
=== Structure and Function === | === Structure and Function === | ||
