1ms1: Difference between revisions
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Revision as of 09:00, 2 June 2012
Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)
Template:ABSTRACT PUBMED 12419220
About this Structure
1ms1 is a 2 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
Reference
- Buschiazzo A, Amaya MF, Cremona ML, Frasch AC, Alzari PM. The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis. Mol Cell. 2002 Oct;10(4):757-68. PMID:12419220
- Demir O, Roitberg AE. Modulation of catalytic function by differential plasticity of the active site: case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase. Biochemistry. 2009 Apr 21;48(15):3398-406. PMID:19216574 doi:10.1021/bi802230y
