2bpz: Difference between revisions
New page: left|200px<br /> <applet load="2bpz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bpz, resolution 2.5Å" /> '''HIV-1 PROTEASE-INHIB... |
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[[Image:2bpz. | [[Image:2bpz.jpg|left|200px]]<br /><applet load="2bpz" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="2bpz, resolution 2.5Å" /> | caption="2bpz, resolution 2.5Å" /> | ||
'''HIV-1 PROTEASE-INHIBITOR COMPLEX'''<br /> | '''HIV-1 PROTEASE-INHIBITOR COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2BPZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with 3IN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.13.16 3.4.13.16] Full crystallographic information is available from [http:// | 2BPZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=3IN:'>3IN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.13.16 3.4.13.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPZ OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:16:38 2008'' | ||
Revision as of 15:16, 15 February 2008
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HIV-1 PROTEASE-INHIBITOR COMPLEX
Overview
The ability to replace an inhibitor bound to the HIV-1 protease in single, crystals with other potent inhibitors offers the possibility of, investigating a series of protease inhibitors rapidly and conveniently, with the use of X-ray crystallography. This approach affords a fast, turnaround of structural information for iterative rational drug designs, and obviates the need for studying the complex structures by, co-crystallization. The replacement approach has been successfully used, with single crystals of the HIV-1 protease complexed with a weak, inhibitor. The structures of the complexes obtained by the replacement, method are similar to those determined by co-crystallization.
About this Structure
2BPZ is a Single protein structure of sequence from Human immunodeficiency virus 1 with 3IN as ligand. Active as Deleted entry, with EC number 3.4.13.16 Full crystallographic information is available from OCA.
Reference
Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme., Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. PMID:9757136
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