Corticosteroid-binding globulin: Difference between revisions

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	==Introduction==		==Introduction==

	Corticosteroid-binding globulin is a blood plasma protein 50 to 60 kDa in size <ref>PMID:13395526 </ref>,<ref>PMID:7074030 </ref>.		Corticosteroid-binding globulin (CBG) is a blood plasma protein 50 to 60 kDa in size <ref>PMID:13395526 </ref>,<ref>PMID:7074030 </ref>. Although it is a member of the serine protease inhibitor (SERPIN) structural family, it does not have any known intrinsic serine protease inhibitor activity <ref>PMID:3143075 </ref>. Its physiological function is conventionally thought to be the transport of the weakly water-soluble hormone, cortisol, throughout the circulation <ref>PMID:13395526 </ref>,<ref>PMID:7074030 </ref>. Structural studies of native rat CBG <ref>PMID:17644521 </ref> and a cleaved human CBG-antitrypsin chimera <ref>PMID:18513745 </ref> have corroborated earlier biochemical studies showing that cortisol binds to CBG with a one-to-one stoichiometry. Additionally, CBG is believed to buffer the concentration of free cortisol in the blood, keeping the level constant despite its pulsatile secretion pattern.

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