Corticosteroid-binding globulin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Wee Lee Chan (talk | contribs) No edit summary |
Wee Lee Chan (talk | contribs) No edit summary |
||
| Line 23: | Line 23: | ||
''(Click'' <scene name='Corticosteroid-binding_globulin/Native/1'>here</scene> ''to return to structure of CBG in the S-state.) | ''(Click'' <scene name='Corticosteroid-binding_globulin/Native/1'>here</scene> ''to return to structure of CBG in the S-state.) | ||
'' | '' | ||
==Ligand-binding== | |||
The structures show that the ligand binds in a <scene name='Corticosteroid-binding_globulin/Pocket/2'>largely hyrdrophobic pocket</scene>, where the main interaction between cortisol and CBG is the pi-pi stacking between a key tryptophan residue (371 in humans), and the steroid ring of cortisol. There is also significant polar interaction between some of the polar side chains of the binding pocket residues and oxygen atoms on cortisol. | |||
==Functions== | ==Functions== | ||
