Corticosteroid-binding globulin: Difference between revisions
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==Ligand-binding== | ==Ligand-binding== | ||
The structures show that the ligand binds in a <scene name='Corticosteroid-binding_globulin/Native/ | The structures show that the ligand binds in a <scene name='Corticosteroid-binding_globulin/Native/8'>largely hydrophobic pocket</scene>, where the main interaction between cortisol and CBG is the pi-pi stacking between a key tryptophan residue (371 in humans), and the steroid ring of cortisol. There is also significant polar interaction between some of the polar side chains of the binding pocket residues and oxygen atoms on cortisol. | ||
==Functions== | ==Functions== | ||
