2f3k: Difference between revisions
New page: left|200px<br /> <applet load="2f3k" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f3k, resolution 1.599Å" /> '''Substrate envelope... |
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[[Image:2f3k. | [[Image:2f3k.jpg|left|200px]]<br /><applet load="2f3k" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''<br /> | '''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2F3K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with PO4 and RO1 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http:// | 2F3K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=RO1:'>RO1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3K OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: substrate envelope]] | [[Category: substrate envelope]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:24:48 2008'' | ||
Revision as of 15:24, 15 February 2008
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Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease
Overview
In our previous crystallographic studies of human immunodeficiency virus, type 1 (HIV-1) protease-substrate complexes, we described a conserved, "envelope" that appears to be important for substrate recognition and the, selection of drug-resistant mutations. In this study, the complex of HIV-1, protease with the inhibitor RO1 was determined and comparison with the, substrate envelope provides a rationale for mutational patterns.
About this Structure
2F3K is a Single protein structure of sequence from Human immunodeficiency virus 1 with PO4 and RO1 as ligands. Active as HIV-1 retropepsin, with EC number 3.4.23.16 Full crystallographic information is available from OCA.
Reference
Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease., Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA, Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:16569872
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