3fxi: Difference between revisions

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{{Seed}}
[[Image:3fxi.png|left|200px]]
[[Image:3fxi.png|left|200px]]


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{{ABSTRACT_PUBMED_19252480}}
{{ABSTRACT_PUBMED_19252480}}


==Disease==
==About this Structure==
Known disease associated with this structure: Endotoxin hyporesponsiveness OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603030 603030]], Colorectal cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603030 603030]], Longevity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603030 603030]], Macular degeneration, age-related, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603030 603030]]
[[3fxi]] is a 4 chain structure of [[Toll-like Receptors]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The November 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXI OCA].


==About this Structure==
==See Also==
3FXI is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXI OCA].
*[[Toll-like Receptors|Toll-like Receptors]]


==Reference==
==Reference==
<ref group="xtra">PMID:19252480</ref><references group="xtra"/>
<ref group="xtra">PMID:019252480</ref><ref group="xtra">PMID:020485341</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Toll-like Receptors]]
[[Category: Kim, H M.]]
[[Category: Kim, H M.]]
[[Category: Lee, J O.]]
[[Category: Lee, J O.]]
[[Category: Park, B S.]]
[[Category: Park, B S.]]
[[Category: Song, D H.]]
[[Category: Song, D H.]]
[[Category: Alternative splicing]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Immune response]]
[[Category: Immune response]]
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[[Category: Leucine rich repeat]]
[[Category: Leucine rich repeat]]
[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 22:12:40 2009''

Revision as of 06:51, 20 June 2012

File:3fxi.png

Template:STRUCTURE 3fxi

Crystal structure of the human TLR4-human MD-2-E.coli LPS Ra complex

Template:ABSTRACT PUBMED 19252480

About this Structure

3fxi is a 4 chain structure of Toll-like Receptors with sequence from Escherichia coli and Homo sapiens. The November 2011 RCSB PDB Molecule of the Month feature on Toll-like Receptors by David Goodsell is 10.2210/rcsb_pdb/mom_2011_11. Full crystallographic information is available from OCA.

See Also

Reference

  1. Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature. 2009 Apr 30;458(7242):1191-5. Epub 2009 Mar 1. PMID:19252480 doi:10.1038/nature07830
  2. Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature. 2010 Jun 17;465(7300):885-90. Epub 2010 May 19. PMID:20485341 doi:10.1038/nature09121

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