3tcp: Difference between revisions

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'''Unreleased structure'''
[[Image:3tcp.jpg|left|200px]]


The entry 3tcp is ON HOLD until Paper Publication
{{STRUCTURE_3tcp|  PDB=3tcp  |  SCENE=  }}


Authors: Liu, J., Yang, C., Simpson, C., DeRyckere, D., Van Deusen, A., Miley, M., Kireev, D.B., Norris-Drouin, J., Sather, S., Hunter, D., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G., Earp, H.S., Graham, D.K, Frye, S., Wang, X.
===Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569===


Description: Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569
{{ABSTRACT_PUBMED_22662287}}
 
==About this Structure==
[[3tcp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TCP OCA].
 
==Reference==
<ref group="xtra">PMID:022662287</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: DeRyckere, D.]]
[[Category: Deusen, A Van.]]
[[Category: Earp, H S.]]
[[Category: Frye, S.]]
[[Category: Graham, D K]]
[[Category: Hunter, D.]]
[[Category: Janzen, W P.]]
[[Category: Johnson, G.]]
[[Category: Kireev, D B.]]
[[Category: Liu, J.]]
[[Category: Machius, M.]]
[[Category: Miley, M.]]
[[Category: Norris-Drouin, J.]]
[[Category: Patel, H S.]]
[[Category: Sather, S.]]
[[Category: Simpson, C.]]
[[Category: Wang, X.]]
[[Category: Yang, C.]]
[[Category: Acute lymphoblastic leukemia]]
[[Category: Rational structure-based drug design]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Tyrosine kinase]]

Revision as of 07:44, 20 June 2012

File:3tcp.jpg

Template:STRUCTURE 3tcp

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569

Template:ABSTRACT PUBMED 22662287

About this Structure

3tcp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Liu J, Yang C, Simpson C, Deryckere D, Van Deusen A, Miley MJ, Kireev D, Norris-Drouin J, Sather S, Hunter D, Korboukh VK, Patel HS, Janzen WP, Machius M, Johnson GL, Earp HS, Graham DK, Frye SV, Wang X. Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett. 2012 Feb 9;3(2):129-134. PMID:22662287

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