Prp8: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 20: | Line 20: | ||
=Structure of Prp8= | =Structure of Prp8= | ||
<Structure load='3SBG' size='500' frame='true' align='right' caption='The C-terminal Fragment of Prp8 (residues 1836-2397)'scene name='Prp8/Different_domains_-_color/1' | <Structure load='3SBG' size='500' frame='true' align='right' caption='The C-terminal Fragment of Prp8 (residues 1836-2397)'scene name='Prp8/Different_domains_-_color/1'</scene> | ||
Prp8's structure can be summarized as an amalgamation of domains from a variety of proteins, each of which has been slightly modified from their conventional forms and are now unique to Prp8. The major features present in Prp8 are a proline rich region, nuclear localization signal, bromodomain, reverse transcriptase-like domain, RNase H-like domain, and finally a metalloprotease/Jab1-like domain <ref name='Prp8, the pivotal protein of the spliceosomal catalytic center evolved from a retroelement-encoded reverse transcriptase'>DOI:10.1261/rna.2396011</ref>. | Prp8's structure can be summarized as an amalgamation of domains from a variety of proteins, each of which has been slightly modified from their conventional forms and are now unique to Prp8. The major features present in Prp8 are a proline rich region, nuclear localization signal, bromodomain, reverse transcriptase-like domain, RNase H-like domain, and finally a metalloprotease/Jab1-like domain <ref name='Prp8, the pivotal protein of the spliceosomal catalytic center evolved from a retroelement-encoded reverse transcriptase'>DOI:10.1261/rna.2396011</ref>. | ||
