4f7v: Difference between revisions

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[[Image:4f7v.jpg|left|200px]]
[[Image:4f7v.png|left|200px]]


{{STRUCTURE_4f7v|  PDB=4f7v  |  SCENE=  }}  
{{STRUCTURE_4f7v|  PDB=4f7v  |  SCENE=  }}  

Revision as of 06:20, 25 July 2012

File:4f7v.png

Template:STRUCTURE 4f7v

Crystal structure of E. coli HPPK in complex with bisubstrate analogue inhibitor J1D (HP26)

Template:ABSTRACT PUBMED 22727779

About this Structure

4f7v is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  1. Shi G, Shaw G, Li Y, Wu Y, Yan H, Ji X. Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode. Bioorg Med Chem. 2012 Jul 15;20(14):4303-9. Epub 2012 Jun 6. PMID:22727779 doi:10.1016/j.bmc.2012.05.060
  2. Shi G, Blaszczyk J, Ji X, Yan H. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71. PMID:11311059
  3. Shi G, Shaw G, Liang YH, Subburaman P, Li Y, Wu Y, Yan H, Ji X. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties. Bioorg Med Chem. 2012 Jan 1;20(1):47-57. Epub 2011 Nov 23. PMID:22169600 doi:10.1016/j.bmc.2011.11.032

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