1a6z: Difference between revisions

[[Image:1a6z.gif|left|200px]]<br /><applet load="1a6z" size="350" color="white" frame="true" align="right" spinBox="true"  

HFE is an MHC-related protein that is mutated in the iron-overload disease hereditary hemochromatosis. HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism. The 2.6 A crystal structure of HFE reveals the locations of hemochromatosis mutations and a patch of histidines that could be involved in pH-dependent interactions. We also demonstrate that soluble TfR and HFE bind tightly at the basic pH of the cell surface, but not at the acidic pH of intracellular vesicles. TfR:HFE stoichiometry (2:1) differs from TfR:transferrin stoichiometry (2:2), implying a different mode of binding for HFE and transferrin to TfR, consistent with our demonstration that HFE, transferrin, and TfR form a ternary complex.

1A6Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6Z OCA].  

[[Category: Bennett, M J.]]

[[Category: Bjorkman, P J.]]

[[Category: Chirino, A J.]]

[[Category: Feder, J N.]]

[[Category: Lebron, J A.]]

[[Category: Mintier, G A.]]

[[Category: Snow, P M.]]

[[Category: Vaughn, D E.]]

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