4axa: Difference between revisions

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'''Unreleased structure'''
[[Image:4axa.jpg|left|200px]]


The entry 4axa is ON HOLD until Paper Publication
{{STRUCTURE_4axa|  PDB=4axa  |  SCENE=  }}


Authors: Davies, T.G., Yap, T.A., Walton, M.I., Grimshaw, K.M., tePoele, R.H., Eve, P.D., Valenti, M.R., deHavenBrandon, A.K., Martins, V., Zetterlund, A., Heaton, S.P., Heinzmann, K., Jones, P.S., Feltell, R.E., Reule, M., Woodhead, S.J., Lyons, J.F., Raynaud, F.I., Eccles, S.A., Workman, P., Thompson, N.T., Garrett, M.D.
===Structure of PKA-PKB chimera complexed with (1S)-2-amino-1-(4- chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethan-1-ol===


Description: Structure of PKA-PKB chimera complexed with (1S)-2-amino-1-(4-chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethan-1-ol
{{ABSTRACT_PUBMED_22781553}}
 
==About this Structure==
[[4axa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXA OCA].
 
==Reference==
<ref group="xtra">PMID:022781553</ref><references group="xtra"/>
[[Category: Bos taurus]]
[[Category: CAMP-dependent protein kinase]]
[[Category: Davies, T G.]]
[[Category: Dehavenbrandon, A K.]]
[[Category: Eccles, S A.]]
[[Category: Eve, P D.]]
[[Category: Feltell, R E.]]
[[Category: Garrett, M D.]]
[[Category: Grimshaw, K M.]]
[[Category: Heaton, S P.]]
[[Category: Heinzmann, K.]]
[[Category: Jones, P S.]]
[[Category: Lyons, J F.]]
[[Category: Martins, V.]]
[[Category: Raynaud, F I.]]
[[Category: Reule, M.]]
[[Category: Tepoele, R H.]]
[[Category: Thompson, N T.]]
[[Category: Valenti, M R.]]
[[Category: Walton, M I.]]
[[Category: Woodhead, S J.]]
[[Category: Workman, P.]]
[[Category: Yap, T A.]]
[[Category: Zetterlund, A.]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 07:10, 25 July 2012

File:4axa.jpg

Template:STRUCTURE 4axa

Structure of PKA-PKB chimera complexed with (1S)-2-amino-1-(4- chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethan-1-ol

Template:ABSTRACT PUBMED 22781553

About this Structure

4axa is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  1. Yap TA, Walton MI, Grimshaw KM, Te Poele RH, Eve PD, Valenti MR, de Haven Brandon AK, Martins V, Zetterlund A, Heaton SP, Heinzmann K, Jones PS, Feltell RE, Reule M, Woodhead SJ, Davies TG, Lyons JF, Raynaud FI, Eccles SA, Workman P, Thompson NT, Garrett MD. AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity. Clin Cancer Res. 2012 Jul 15;18(14):3912-23. Epub 2012 Jul 10. PMID:22781553 doi:10.1158/1078-0432.CCR-11-3313

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