3o0u: Difference between revisions

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[[Image:3o0u.jpg|left|200px]]
[[Image:3o0u.png|left|200px]]


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{{STRUCTURE_3o0u|  PDB=3o0u  |  SCENE=  }}  
{{STRUCTURE_3o0u|  PDB=3o0u  |  SCENE=  }}  


===Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG===
===Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG===


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{{ABSTRACT_PUBMED_20843687}}
{{ABSTRACT_PUBMED_20843687}}


==About this Structure==
==About this Structure==
[[3o0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O0U OCA].  
[[3o0u]] is a 1 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O0U OCA].  
 
==See Also==
*[[Cathepsin|Cathepsin]]


==Reference==
==Reference==
<ref group="xtra">PMID:20843687</ref><references group="xtra"/>
<ref group="xtra">PMID:020843687</ref><references group="xtra"/>
[[Category: Cathepsin K]]
[[Category: Cathepsin K]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 28: Line 20:
[[Category: Uitdehaag, J C.M.]]
[[Category: Uitdehaag, J C.M.]]
[[Category: Zeeland, M van.]]
[[Category: Zeeland, M van.]]
[[Category: Bone]]
[[Category: Covalent 2-cyano-pyrimidine inhibitor]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Reversible covalent bond between cys25 and ligand]]

Revision as of 10:05, 25 July 2012

File:3o0u.png

Template:STRUCTURE 3o0u

Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG

Template:ABSTRACT PUBMED 20843687

About this Structure

3o0u is a 1 chain structure of Cathepsin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Rankovic Z, Cai J, Kerr J, Fradera X, Robinson J, Mistry A, Finlay W, McGarry G, Andrews F, Caulfield W, Cumming I, Dempster M, Waller J, Arbuckle W, Anderson M, Martin I, Mitchell A, Long C, Baugh M, Westwood P, Kinghorn E, Jones P, Uitdehaag JC, van Zeeland M, Potin D, Saniere L, Fouquet A, Chevallier F, Deronzier H, Dorleans C, Nicolai E. Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG. Bioorg Med Chem Lett. 2010 Aug 24. PMID:20843687 doi:10.1016/j.bmcl.2010.08.101

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