1u71: Difference between revisions

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[[Image:1u71.png|left|200px]]
[[Image:1u71.png|left|200px]]


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{{STRUCTURE_1u71|  PDB=1u71  |  SCENE=  }}  
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===Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH===
===Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH===


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{{ABSTRACT_PUBMED_15681865}}


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==See Also==
==See Also==
*[[Dihydrofolate reductase]]
*[[Dihydrofolate reductase|Dihydrofolate reductase]]


==Reference==
==Reference==
<ref group="xtra">PMID:15681865</ref><references group="xtra"/>
<ref group="xtra">PMID:015681865</ref><references group="xtra"/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 10:32, 25 July 2012

File:1u71.png

Template:STRUCTURE 1u71

Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH

Template:ABSTRACT PUBMED 15681865

About this Structure

1u71 is a 1 chain structure of Dihydrofolate reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Cody V, Luft JR, Pangborn W. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr D Biol Crystallogr. 2005 Feb;61(Pt 2):147-55. Epub 2005, Jan 19. PMID:15681865 doi:https://dx.doi.org/10.1107/S0907444904030422

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