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[[Image:3kle.png|left|200px]]
[[Image:3kle.png|left|200px]]


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{{STRUCTURE_3kle|  PDB=3kle  |  SCENE=  }}  
{{STRUCTURE_3kle|  PDB=3kle  |  SCENE=  }}  


===Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA===
===Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA===


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{{ABSTRACT_PUBMED_20852643}}
{{ABSTRACT_PUBMED_20852643}}


==About this Structure==
==About this Structure==
[[3kle]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLE OCA].  
[[3kle]] is a 16 chain structure of [[AZT-resistant HIV-1 reverse transcriptase]] and [[Reverse transcriptase]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLE OCA].  


==See Also==
==See Also==
*[[AZT-resistant HIV-1 reverse transcriptase]]
*[[AZT-resistant HIV-1 reverse transcriptase|AZT-resistant HIV-1 reverse transcriptase]]
*[[Phl p 2]]
*[[Phl p 2|Phl p 2]]
*[[Reverse transcriptase|Reverse transcriptase]]


==Reference==
==Reference==
<ref group="xtra">PMID:20852643</ref><references group="xtra"/>
<ref group="xtra">PMID:020852643</ref><references group="xtra"/>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Arnold, E.]]
[[Category: Arnold, E.]]
Line 32: Line 22:
[[Category: Sarafianos, S G.]]
[[Category: Sarafianos, S G.]]
[[Category: Tu, X.]]
[[Category: Tu, X.]]
[[Category: Aid]]
[[Category: Azt]]
[[Category: Azt adenosine dinucleoside tetraphosphate]]
[[Category: Azt resistance mechanism]]
[[Category: Aztp4a]]
[[Category: Aztppppa]]
[[Category: Dna polymerase]]
[[Category: Dna-directed dna polymerase]]
[[Category: Endonuclease]]
[[Category: Hiv]]
[[Category: Hiv-1]]
[[Category: Hydrolase]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Multifunctional enzyme]]
[[Category: Myristate]]
[[Category: Nrti]]
[[Category: Nrti resistance]]
[[Category: Nuclease]]
[[Category: Nucleoside inhibitor]]
[[Category: Nucleotide excision]]
[[Category: P51/p66]]
[[Category: Resistance mutation]]
[[Category: Reverse transcriptase]]
[[Category: Rna-directed dna polymerase]]
[[Category: Rt]]
[[Category: Thymidine analog mutation]]
[[Category: Transferase]]
[[Category: Transferase-dna complex]]

Revision as of 12:50, 25 July 2012

File:3kle.png

Template:STRUCTURE 3kle

Crystal structure of AZT-resistant HIV-1 Reverse Transcriptase crosslinked to a DSDNA with a bound excision product, AZTPPPPA

Template:ABSTRACT PUBMED 20852643

About this Structure

3kle is a 16 chain structure of AZT-resistant HIV-1 reverse transcriptase and Reverse transcriptase with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

See Also

Reference

  1. Tu X, Das K, Han Q, Bauman JD, Clark AD Jr, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E. Structural basis of HIV-1 resistance to AZT by excision. Nat Struct Mol Biol. 2010 Oct;17(10):1202-9. Epub 2010 Sep 19. PMID:20852643 doi:10.1038/nsmb.1908

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