3fkt: Difference between revisions

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{{Seed}}
[[Image:3fkt.png|left|200px]]
[[Image:3fkt.jpg|left|200px]]


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{{STRUCTURE_3fkt|  PDB=3fkt  |  SCENE=  }}  
{{STRUCTURE_3fkt|  PDB=3fkt  |  SCENE=  }}  


===Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor===
===Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor===


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{{ABSTRACT_PUBMED_18811140}}
{{ABSTRACT_PUBMED_18811140}}


==About this Structure==
==About this Structure==
3FKT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3e3w 3e3w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKT OCA].  
[[3fkt]] is a 1 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3e3w 3e3w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKT OCA].  
 
==See Also==
*[[Beta secretase|Beta secretase]]


==Reference==
==Reference==
<ref group="xtra">PMID:18811140</ref><references group="xtra"/>
<ref group="xtra">PMID:018811140</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
[[Category: Munshi, S.]]
[[Category: Munshi, S.]]
[[Category: Alternative splicing]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Bace]]
[[Category: Bace]]
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:48:24 2009''

Revision as of 13:23, 25 July 2012

File:3fkt.png

Template:STRUCTURE 3fkt

Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor

Template:ABSTRACT PUBMED 18811140

About this Structure

3fkt is a 1 chain structure of Beta secretase with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3e3w. Full crystallographic information is available from OCA.

See Also

Reference

  1. Barrow JC, Stauffer SR, Rittle KE, Ngo PL, Yang Z, Selnick HG, Graham SL, Munshi S, McGaughey GB, Holloway MK, Simon AJ, Price EA, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Espeseth AS, Xu M, Huang Q, Wolfe A, Pietrak B, Zuck P, Levorse DA, Hazuda D, Vacca JP. Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase. J Med Chem. 2008 Oct 23;51(20):6259-62. Epub 2008 Sep 24. PMID:18811140 doi:10.1021/jm800914n

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