1awc: Difference between revisions

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[[Image:1awc.gif|left|200px]]<br /><applet load="1awc" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1awc.gif|left|200px]]<br /><applet load="1awc" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1awc, resolution 2.150Å" />

'''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''<br />

==Overview==

GA-binding protein (GABP) is a transcriptional regulator composed of two, structurally dissimilar subunits. The alpha subunit contains a DNA-binding, domain that is a member of the ETS family, whereas the beta subunit, contains a series of ankyrin repeats. The crystal structure of a ternary, complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer, bound to DNA was determined at 2. 15 angstrom resolution. The structure, shows how an ETS domain protein can recruit a partner protein using both, the ETS domain and a carboxyl-terminal extension and provides a view of an, extensive protein-protein interface formed by a set of ankyrin repeats., The structure also reveals how the GABPalpha ETS domain binds to its core, GGA DNA-recognition motif.

GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.

==About this Structure==

1AWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA].

1AWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA].

==Reference==

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[[Category: Mus musculus]]

[[Category: Protein complex]]

[[Category: Batchelor, A.H.]]

[[Category: Batchelor, A H.]]

[[Category: Wolberger, C.]]

[[Category: ankyrin repeats]]

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[[Category: transcription factor]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:55 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1awc.gif|left|200px]]<br /><applet load="1awc" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1awc.gif|left|200px]]<br /><applet load="1awc" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1awc, resolution 2.150&Aring;" />
 '''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''<br />
 ==Overview==
-GA-binding protein (GABP) is a transcriptional regulator composed of two, structurally dissimilar subunits. The alpha subunit contains a DNA-binding, domain that is a member of the ETS family, whereas the beta subunit, contains a series of ankyrin repeats. The crystal structure of a ternary, complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer, bound to DNA was determined at 2. 15 angstrom resolution. The structure, shows how an ETS domain protein can recruit a partner protein using both, the ETS domain and a carboxyl-terminal extension and provides a view of an, extensive protein-protein interface formed by a set of ankyrin repeats., The structure also reveals how the GABPalpha ETS domain binds to its core, GGA DNA-recognition motif.
+GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.
 ==About this Structure==
-AWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA].
+AWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
-[[Category: Batchelor, A.H.]]
+[[Category: Batchelor, A H.]]
 [[Category: Wolberger, C.]]
 [[Category: ankyrin repeats]]
@@ Line 22: / Line 22: @@
 [[Category: transcription factor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:10:21 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:55 2008''