1w50: Difference between revisions

Revision as of 13:58, 25 July 2012

Ligands:

IOD

Activity:

Memapsin 2, with EC number 3.4.23.46

Related:

1fkn, 1m4h, 1py1, 1sgz, 1ujj, 1ujk, 1w51

Structural annotation:
Resources:	CATH : 1W50A01, 1W50A02 InterPro : Ipr001969, Ipr001461, Ipr009007, Ipr009120, Ipr009119 Pfam : PF00026 SCOP : d1w50a_ UniProt : P56817

Functional annotation:
Cellular component:	Golgi apparatus endosome integral to membrane integral to plasma membrane membrane
Biological process:	proteolysis beta-amyloid metabolic process membrane protein ectodomain proteolysis
Molecular function:	aspartic-type signal peptidase activity aspartic-type endopeptidase activity pepsin A activity peptidase activity beta-aspartyl-peptidase activity hydrolase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1w50 is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Patel S, Vuillard L, Cleasby A, Murray CW, Yon J. Apo and inhibitor complex structures of BACE (beta-secretase). J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669 doi:10.1016/j.jmb.2004.08.018

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