4dbs: Difference between revisions

Revision as of 15:51, 25 July 2012

4dbs is a 2 chain structure of Hydroxysteroid dehydrogenase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Chen M, Adeniji AO, Twenter BM, Winkler JD, Christianson DW, Penning TM. Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. Bioorg Med Chem Lett. 2012 Mar 29. PMID:22507964 doi:10.1016/j.bmcl.2012.03.085

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 [[Image:4dbs.png|left|200px]]
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 ===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3'-[(4-nitronaphthalen-1-yl)amino]benzoic acid===
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