1b8w: Difference between revisions

[[Image:1b8w.jpg|left|200px]]<br /><applet load="1b8w" size="350" color="white" frame="true" align="right" spinBox="true"  

Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel beta-sheet comprising residues 15-18 and 37-40 and a small 3(10) helix spanning residues 10-12. The overall three-dimensional fold is similar to that of beta-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthus neurotoxin I). However, the side chains known to be functionally important in beta-defensin-12 and ShI are not conserved in DLP-1, suggesting that it has a different biological function. Consistent with this contention, we showed that DLP-1 possesses no anti-microbial properties and has no observable activity on rat dorsal-root-ganglion sodium-channel currents.

1B8W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Ornithorhynchus_anatinus Ornithorhynchus anatinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8W OCA].  

[[Category: Alewood, P F.]]

[[Category: Fletcher, J I.]]

[[Category: Gallagher, C H.]]

[[Category: King, G F.]]

[[Category: Kuchel, P W.]]

[[Category: Nicholson, G M.]]

[[Category: Simpson, R J.]]

[[Category: Sutherland, S K.]]

[[Category: Torres, A M.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:52:45 2008''