1j3j: Difference between revisions

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[[Image:1j3j.png|left|200px]]
[[Image:1j3j.png|left|200px]]


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{{STRUCTURE_1j3j|  PDB=1j3j  |  SCENE=  }}  
{{STRUCTURE_1j3j|  PDB=1j3j  |  SCENE=  }}  


===Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP===
===Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP===


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{{ABSTRACT_PUBMED_12704428}}
{{ABSTRACT_PUBMED_12704428}}


==About this Structure==
==About this Structure==
[[1j3j]] is a 4 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3J OCA].  
[[1j3j]] is a 4 chain structure of [[Dihydrofolate reductase]] and [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3J OCA].  


==See Also==
==See Also==
*[[Dihydrofolate reductase]]
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
*[[Thymidylate synthase|Thymidylate synthase]]


==Reference==
==Reference==
<ref group="xtra">PMID:12704428</ref><references group="xtra"/>
<ref group="xtra">PMID:012704428</ref><references group="xtra"/>
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Chitnumsub, P.]]
[[Category: Chitnumsub, P.]]

Revision as of 16:26, 25 July 2012

File:1j3j.png

Template:STRUCTURE 1j3j

Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP

Template:ABSTRACT PUBMED 12704428

About this Structure

1j3j is a 4 chain structure of Dihydrofolate reductase and Thymidylate synthase with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

See Also

Reference

  1. Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y. Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol. 2003 May;10(5):357-65. PMID:12704428 doi:10.1038/nsb921

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