1boy: Difference between revisions

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==Overview==

Tissue factor is a cell-surface glycoprotein receptor which initiates the, blood coagulation cascade after vessel injury by interacting with blood, clotting factor VII/VIIa and which is implicated in various pathological, processes. When bound to tissue factor, factor VII is readily converted to, the active protease factor VIIa by trace amounts of factors Xa, IXa or, VIIa. Human tissue factor consists of 263 residues, the first 219 of which, comprise the extracellular region. We have determined the crystal, structure of the extracellular region at a resolution of 2.2 A. Tissue, factor consists of two immunoglobulin-like domains associated through an, extensive, novel, interdomain interface region. The binding site for, factor VII lies at the interface region and involves residues from domain, 1 and an extended loop (binding 'finger') of domain 2. This is the first, reported structure of a representative of the class 2 cytokine receptor, family, which also includes interferon-alpha, interferon-gamma (refs 2, 3), and interleukin-10 (ref. 4) receptors.

Tissue factor is a cell-surface glycoprotein receptor which initiates the blood coagulation cascade after vessel injury by interacting with blood clotting factor VII/VIIa and which is implicated in various pathological processes. When bound to tissue factor, factor VII is readily converted to the active protease factor VIIa by trace amounts of factors Xa, IXa or VIIa. Human tissue factor consists of 263 residues, the first 219 of which comprise the extracellular region. We have determined the crystal structure of the extracellular region at a resolution of 2.2 A. Tissue factor consists of two immunoglobulin-like domains associated through an extensive, novel, interdomain interface region. The binding site for factor VII lies at the interface region and involves residues from domain 1 and an extended loop (binding 'finger') of domain 2. This is the first reported structure of a representative of the class 2 cytokine receptor family, which also includes interferon-alpha, interferon-gamma (refs 2, 3) and interleukin-10 (ref. 4) receptors.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Boys, C.W.G.]]

[[Category: Boys, C W.G.]]

[[Category: Harlos, K.]]

[[Category: Tuddenham, E.G.D.]]

[[Category: Tuddenham, E G.D.]]

[[Category: blood coagulation]]

[[Category: class 2 cytokine receptor]]

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[[Category: initiator of blood coagulation in vertebrates]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Tissue factor is a cell-surface glycoprotein receptor which initiates the, blood coagulation cascade after vessel injury by interacting with blood, clotting factor VII/VIIa and which is implicated in various pathological, processes. When bound to tissue factor, factor VII is readily converted to, the active protease factor VIIa by trace amounts of factors Xa, IXa or, VIIa. Human tissue factor consists of 263 residues, the first 219 of which, comprise the extracellular region. We have determined the crystal, structure of the extracellular region at a resolution of 2.2 A. Tissue, factor consists of two immunoglobulin-like domains associated through an, extensive, novel, interdomain interface region. The binding site for, factor VII lies at the interface region and involves residues from domain, 1 and an extended loop (binding 'finger') of domain 2. This is the first, reported structure of a representative of the class 2 cytokine receptor, family, which also includes interferon-alpha, interferon-gamma (refs 2, 3), and interleukin-10 (ref. 4) receptors.
+Tissue factor is a cell-surface glycoprotein receptor which initiates the blood coagulation cascade after vessel injury by interacting with blood clotting factor VII/VIIa and which is implicated in various pathological processes. When bound to tissue factor, factor VII is readily converted to the active protease factor VIIa by trace amounts of factors Xa, IXa or VIIa. Human tissue factor consists of 263 residues, the first 219 of which comprise the extracellular region. We have determined the crystal structure of the extracellular region at a resolution of 2.2 A. Tissue factor consists of two immunoglobulin-like domains associated through an extensive, novel, interdomain interface region. The binding site for factor VII lies at the interface region and involves residues from domain 1 and an extended loop (binding 'finger') of domain 2. This is the first reported structure of a representative of the class 2 cytokine receptor family, which also includes interferon-alpha, interferon-gamma (refs 2, 3) and interleukin-10 (ref. 4) receptors.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Boys, C.W.G.]]
+[[Category: Boys, C W.G.]]
 [[Category: Harlos, K.]]
-[[Category: Tuddenham, E.G.D.]]
+[[Category: Tuddenham, E G.D.]]
 [[Category: blood coagulation]]
 [[Category: class 2 cytokine receptor]]
@@ Line 25: / Line 25: @@
 [[Category: initiator of blood coagulation in vertebrates]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:33:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:57:31 2008''