3okh: Difference between revisions

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[[Image:3okh.jpg|left|200px]]
[[Image:3okh.png|left|200px]]


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{{STRUCTURE_3okh|  PDB=3okh  |  SCENE=  }}  
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===Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid===
===Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid===


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{{ABSTRACT_PUBMED_21134747}}
{{ABSTRACT_PUBMED_21134747}}


==About this Structure==
==About this Structure==
[[3okh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OKH OCA].  
[[3okh]] is a 2 chain structure of [[Hormone]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OKH OCA].  
 
==See Also==
*[[Hormone|Hormone]]


==Reference==
==Reference==
<ref group="xtra">PMID:21134747</ref><references group="xtra"/>
<ref group="xtra">PMID:021134747</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Rudolph, M G.]]
[[Category: Rudolph, M G.]]
[[Category: Bile acid]]
[[Category: Cholesterol]]
[[Category: Coactivator]]
[[Category: Dna-binding]]
[[Category: Fxr alternative splicing]]
[[Category: Hormone receptor]]
[[Category: Ligand binding domain transcription regulation]]
[[Category: Nuclear receptor]]
[[Category: Nucleus]]
[[Category: Receptor]]
[[Category: Transcription]]

Revision as of 19:31, 25 July 2012

File:3okh.png

Template:STRUCTURE 3okh

Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid

Template:ABSTRACT PUBMED 21134747

About this Structure

3okh is a 2 chain structure of Hormone with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Richter HG, Benson GM, Blum D, Chaput E, Feng S, Gardes C, Grether U, Hartman P, Kuhn B, Martin RE, Plancher JM, Rudolph MG, Schuler F, Taylor S, Bleicher KH. Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes. Bioorg Med Chem Lett. 2011 Jan 1;21(1):191-4. Epub 2010 Nov 12. PMID:21134747 doi:10.1016/j.bmcl.2010.11.039

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