1bt7: Difference between revisions
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==Overview== | ==Overview== | ||
The solution structure of the hepatitis C virus (BK strain) NS3 protein | The solution structure of the hepatitis C virus (BK strain) NS3 protein N-terminal domain (186 residues) has been solved by NMR spectroscopy. The protein is a serine protease with a chymotrypsin-type fold, and is involved in the maturation of the viral polyprotein. Despite the knowledge that its activity is enhanced by the action of a viral protein cofactor, NS4A, the mechanism of activation is not yet clear. The analysis of the folding in solution and the differences from the crystallographic structures allow the formulation of a model in which, in addition to the NS4A cofactor, the substrate plays an important role in the activation of the catalytic mechanism. A unique structural feature is the presence of a zinc-binding site exposed on the surface, subject to a slow conformational exchange process. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Barbato, G.]] | [[Category: Barbato, G.]] | ||
[[Category: Bazzo, R.]] | [[Category: Bazzo, R.]] | ||
[[Category: Cicero, D | [[Category: Cicero, D O.]] | ||
[[Category: Cortese, R.]] | [[Category: Cortese, R.]] | ||
[[Category: Francesco, R | [[Category: Francesco, R De.]] | ||
[[Category: Nardi, M | [[Category: Nardi, M C.]] | ||
[[Category: Steinkuhler, C.]] | [[Category: Steinkuhler, C.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: viral non-structural protein]] | [[Category: viral non-structural protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:58:49 2008'' | ||
