1bvj: Difference between revisions

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[[Image:1bvj.gif|left|200px]]<br />

[[Image:1bvj.gif|left|200px]]<br /><applet load="1bvj" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1bvj" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1bvj" />

'''HIV-1 RNA A-RICH HAIRPIN LOOP'''<br />

==Overview==

Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral, reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates, complex formation between tRNA and viral RNA. We have determined the, structure of an A-rich loop oligonucleotide using nuclear magnetic, resonance spectroscopy. The loop structure is stabilized by a noncanonical, G-A pair and a U-turn motif, which leads to stacking of the conserved, adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse, transcription.

Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.

==About this Structure==

1BVJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hevea Hevea]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA].

1BVJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hevea Hevea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA].

==Reference==

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[[Category: Hevea]]

[[Category: Single protein]]

[[Category: Puglisi, E.V.]]

[[Category: Puglisi, E V.]]

[[Category: Puglisi, J.D.]]

[[Category: Puglisi, J D.]]

[[Category: hiv-1 genomic rna]]

[[Category: reverse transcriptase initiation]]

[[Category: rna hairpin loop]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on Thu ~~Nov 8 13~~:55:~~00 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:31 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1bvj.gif|left|200px]]<br />
+[[Image:1bvj.gif|left|200px]]<br /><applet load="1bvj" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1bvj" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1bvj" />
 '''HIV-1 RNA A-RICH HAIRPIN LOOP'''<br />
 ==Overview==
-Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral, reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates, complex formation between tRNA and viral RNA. We have determined the, structure of an A-rich loop oligonucleotide using nuclear magnetic, resonance spectroscopy. The loop structure is stabilized by a noncanonical, G-A pair and a U-turn motif, which leads to stacking of the conserved, adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse, transcription.
+Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.
 ==About this Structure==
-BVJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hevea Hevea]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA].
+BVJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hevea Hevea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Hevea]]
 [[Category: Single protein]]
-[[Category: Puglisi, E.V.]]
+[[Category: Puglisi, E V.]]
-[[Category: Puglisi, J.D.]]
+[[Category: Puglisi, J D.]]
 [[Category: hiv-1 genomic rna]]
 [[Category: reverse transcriptase initiation]]
 [[Category: rna hairpin loop]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 13:55:00 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:31 2008''