1bxl: Difference between revisions

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[[Image:1bxl.gif|left|200px]]<br />

[[Image:1bxl.gif|left|200px]]<br /><applet load="1bxl" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1bxl" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1bxl" />

'''STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE'''<br />

==Overview==

Heterodimerization between members of the Bcl-2 family of proteins is a, key event in the regulation of programmed cell death. The molecular basis, for heterodimer formation was investigated by determination of the, solution structure of a complex between the survival protein Bcl-xL and, the death-promoting region of the Bcl-2-related protein Bak. The structure, and binding affinities of mutant Bak peptides indicate that the Bak, peptide adopts an amphipathic alpha helix that interacts with Bcl-xL, through hydrophobic and electrostatic interactions. Mutations in, full-length Bak that disrupt either type of interaction inhibit the, ability of Bak to heterodimerize with Bcl-xL.

Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for heterodimer formation was investigated by determination of the solution structure of a complex between the survival protein Bcl-xL and the death-promoting region of the Bcl-2-related protein Bak. The structure and binding affinities of mutant Bak peptides indicate that the Bak peptide adopts an amphipathic alpha helix that interacts with Bcl-xL through hydrophobic and electrostatic interactions. Mutations in full-length Bak that disrupt either type of interaction inhibit the ability of Bak to heterodimerize with Bcl-xL.

==About this Structure==

1BXL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1BXL OCA].

1BXL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXL OCA].

==Reference==

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[[Category: Escherichia coli]]

[[Category: Protein complex]]

[[Category: Chang, B.S.]]

[[Category: Chang, B S.]]

[[Category: Eberstadt, M.]]

[[Category: Fesik, S.W.]]

[[Category: Fesik, S W.]]

[[Category: Harlan, J.E.]]

[[Category: Harlan, J E.]]

[[Category: Liang, H.]]

[[Category: Meadows, R.P.]]

[[Category: Meadows, R P.]]

[[Category: Minn, A.J.]]

[[Category: Minn, A J.]]

[[Category: Nettesheim, D.]]

[[Category: Sattler, M.]]

[[Category: Shuker, S.B.]]

[[Category: Shuker, S B.]]

[[Category: Thompson, C.B.]]

[[Category: Thompson, C B.]]

[[Category: Yoon, H.]]

[[Category: alternative splicing]]

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[[Category: complex (apoptosis/peptide)]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:15:~~14 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:00:09 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1bxl.gif|left|200px]]<br />
+[[Image:1bxl.gif|left|200px]]<br /><applet load="1bxl" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1bxl" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1bxl" />
 '''STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE'''<br />
 ==Overview==
-Heterodimerization between members of the Bcl-2 family of proteins is a, key event in the regulation of programmed cell death. The molecular basis, for heterodimer formation was investigated by determination of the, solution structure of a complex between the survival protein Bcl-xL and, the death-promoting region of the Bcl-2-related protein Bak. The structure, and binding affinities of mutant Bak peptides indicate that the Bak, peptide adopts an amphipathic alpha helix that interacts with Bcl-xL, through hydrophobic and electrostatic interactions. Mutations in, full-length Bak that disrupt either type of interaction inhibit the, ability of Bak to heterodimerize with Bcl-xL.
+Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for heterodimer formation was investigated by determination of the solution structure of a complex between the survival protein Bcl-xL and the death-promoting region of the Bcl-2-related protein Bak. The structure and binding affinities of mutant Bak peptides indicate that the Bak peptide adopts an amphipathic alpha helix that interacts with Bcl-xL through hydrophobic and electrostatic interactions. Mutations in full-length Bak that disrupt either type of interaction inhibit the ability of Bak to heterodimerize with Bcl-xL.
 ==About this Structure==
-BXL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BXL OCA].
+BXL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXL OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Escherichia coli]]
 [[Category: Protein complex]]
-[[Category: Chang, B.S.]]
+[[Category: Chang, B S.]]
 [[Category: Eberstadt, M.]]
-[[Category: Fesik, S.W.]]
+[[Category: Fesik, S W.]]
-[[Category: Harlan, J.E.]]
+[[Category: Harlan, J E.]]
 [[Category: Liang, H.]]
-[[Category: Meadows, R.P.]]
+[[Category: Meadows, R P.]]
-[[Category: Minn, A.J.]]
+[[Category: Minn, A J.]]
 [[Category: Nettesheim, D.]]
 [[Category: Sattler, M.]]
-[[Category: Shuker, S.B.]]
+[[Category: Shuker, S B.]]
-[[Category: Thompson, C.B.]]
+[[Category: Thompson, C B.]]
 [[Category: Yoon, H.]]
 [[Category: alternative splicing]]
@@ Line 30: / Line 29: @@
 [[Category: complex (apoptosis/peptide)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:15:14 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:00:09 2008''