1c16: Difference between revisions

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[[Image:1c16.gif|left|200px]]<br />

[[Image:1c16.gif|left|200px]]<br /><applet load="1c16" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1c16" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1c16, resolution 3.10Å" />

'''CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22'''<br />

==Overview==

Murine T10 and T22 are highly related nonclassical major, histocompatibility complex (MHC) class Ib proteins that bind to certain, gammadelta T cell receptors (TCRs) in the absence of other components. The, crystal structure of T22b at 3.1 angstroms reveals similarities to MHC, class I molecules, but one side of the normal peptide-binding groove is, severely truncated, which allows direct access to the beta-sheet floor., Potential gammadelta TCR-binding sites can be inferred from functional, mapping of T10 and T22 point mutants and allelic variants. Thus, T22, represents an unusual variant of the MHC-like fold and indicates that, gammadelta and alphabeta TCRs interact differently with their respective, MHC ligands.

Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class Ib proteins that bind to certain gammadelta T cell receptors (TCRs) in the absence of other components. The crystal structure of T22b at 3.1 angstroms reveals similarities to MHC class I molecules, but one side of the normal peptide-binding groove is severely truncated, which allows direct access to the beta-sheet floor. Potential gammadelta TCR-binding sites can be inferred from functional mapping of T10 and T22 point mutants and allelic variants. Thus, T22 represents an unusual variant of the MHC-like fold and indicates that gammadelta and alphabeta TCRs interact differently with their respective MHC ligands.

==Disease==

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==About this Structure==

1C16 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1C16 OCA].

1C16 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C16 OCA].

==Reference==

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[[Category: Protein complex]]

[[Category: Chien, Y.]]

[[Category: Crowley, M.P.]]

[[Category: Crowley, M P.]]

[[Category: Degano, M.]]

[[Category: Wilson, I.A.]]

[[Category: Wilson, I A.]]

[[Category: Wingren, C.]]

[[Category: beta2-microglobulin]]

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[[Category: non-classical mhc-like]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:16:~~35 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:01:20 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1c16.gif|left|200px]]<br />
+[[Image:1c16.gif|left|200px]]<br /><applet load="1c16" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1c16" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1c16, resolution 3.10&Aring;" />
 '''CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22'''<br />
 ==Overview==
-Murine T10 and T22 are highly related nonclassical major, histocompatibility complex (MHC) class Ib proteins that bind to certain, gammadelta T cell receptors (TCRs) in the absence of other components. The, crystal structure of T22b at 3.1 angstroms reveals similarities to MHC, class I molecules, but one side of the normal peptide-binding groove is, severely truncated, which allows direct access to the beta-sheet floor., Potential gammadelta TCR-binding sites can be inferred from functional, mapping of T10 and T22 point mutants and allelic variants. Thus, T22, represents an unusual variant of the MHC-like fold and indicates that, gammadelta and alphabeta TCRs interact differently with their respective, MHC ligands.
+Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class Ib proteins that bind to certain gammadelta T cell receptors (TCRs) in the absence of other components. The crystal structure of T22b at 3.1 angstroms reveals similarities to MHC class I molecules, but one side of the normal peptide-binding groove is severely truncated, which allows direct access to the beta-sheet floor. Potential gammadelta TCR-binding sites can be inferred from functional mapping of T10 and T22 point mutants and allelic variants. Thus, T22 represents an unusual variant of the MHC-like fold and indicates that gammadelta and alphabeta TCRs interact differently with their respective MHC ligands.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-C16 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C16 OCA].
+C16 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C16 OCA].
 ==Reference==
@@ Line 19: / Line 18: @@
 [[Category: Protein complex]]
 [[Category: Chien, Y.]]
-[[Category: Crowley, M.P.]]
+[[Category: Crowley, M P.]]
 [[Category: Degano, M.]]
-[[Category: Wilson, I.A.]]
+[[Category: Wilson, I A.]]
 [[Category: Wingren, C.]]
 [[Category: beta2-microglobulin]]
@@ Line 27: / Line 26: @@
 [[Category: non-classical mhc-like]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:16:35 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:01:20 2008''