3n2u: Difference between revisions

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[[Image:3n2u.png|left|200px]]
[[Image:3n2u.png|left|200px]]


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{{STRUCTURE_3n2u|  PDB=3n2u  |  SCENE=  }}  
{{STRUCTURE_3n2u|  PDB=3n2u  |  SCENE=  }}  


===Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(4-methoxy-N(2-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)acetamide===
===Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(4-methoxy-N(2-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)acetamide===


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{{ABSTRACT_PUBMED_20965620}}
{{ABSTRACT_PUBMED_20965620}}


==About this Structure==
==About this Structure==
[[3n2u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2U OCA].  
[[3n2u]] is a 1 chain structure of [[Elastase]] and [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2U OCA].  
 
==See Also==
*[[Elastase|Elastase]]
*[[Matrix metalloproteinase|Matrix metalloproteinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:20965620</ref><ref group="xtra">PMID:17269766</ref><references group="xtra"/>
<ref group="xtra">PMID:020965620</ref><ref group="xtra">PMID:017269766</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Macrophage elastase]]
[[Category: Macrophage elastase]]

Revision as of 22:18, 25 July 2012

File:3n2u.png

Template:STRUCTURE 3n2u

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(4-methoxy-N(2-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)acetamide

Template:ABSTRACT PUBMED 20965620

About this Structure

3n2u is a 1 chain structure of Elastase and Matrix metalloproteinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Attolino E, Calderone V, Dragoni E, Fragai M, Richichi B, Luchinat C, Nativi C. Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). Eur J Med Chem. 2010 Oct 19. PMID:20965620 doi:10.1016/j.ejmech.2010.09.057
  2. Bertini I, Calderone V, Fragai M, Giachetti A, Loconte M, Luchinat C, Maletta M, Nativi C, Yeo KJ. Exploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinases. J Am Chem Soc. 2007 Mar 7;129(9):2466-75. Epub 2007 Feb 2. PMID:17269766 doi:10.1021/ja065156z

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