1a9u: Difference between revisions

Revision as of 23:34, 25 July 2012

Ligands:

SB2

Structural annotation:
Resources:	CATH : 1A9U001, 1A9U002 InterPro : Ipr003527, Ipr008352, Ipr002290, Ipr008271, Ipr000719, Ipr011009 Pfam : PF00069 SCOP : d1a9u__ UniProt : Q16539

Functional annotation:
Cellular component:	cytoplasm nucleus
Biological process:	protein amino acid phosphorylation protein kinase cascade cell surface receptor linked signal transduction cell motility response to stress chemotaxis signal transduction
Molecular function:	protein kinase activity MP kinase activity transferase activity nucleotide binding MAP kinase kinase activity protein binding kinase activity ATP binding MAP kinase activity protein serine/threonine kinase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

1a9u is a 1 chain structure of Mitogen-activated protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Wang Z, Canagarajah BJ, Boehm JC, Kassisa S, Cobb MH, Young PR, Abdel-Meguid S, Adams JL, Goldsmith EJ. Structural basis of inhibitor selectivity in MAP kinases. Structure. 1998 Sep 15;6(9):1117-28. PMID:9753691
Gum RJ, McLaughlin MM, Kumar S, Wang Z, Bower MJ, Lee JC, Adams JL, Livi GP, Goldsmith EJ, Young PR. Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket. J Biol Chem. 1998 Jun 19;273(25):15605-10. PMID:9624152
Avvakumov GV, Walker JR, Xue S, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S. Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). J Biol Chem. 2006 Dec 8;281(49):38061-70. Epub 2006 Oct 11. PMID:17035239 doi:10.1074/jbc.M606704200

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