3lzb: Difference between revisions

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[[Image:3lzb.png|left|200px]]
[[Image:3lzb.png|left|200px]]


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{{STRUCTURE_3lzb|  PDB=3lzb  |  SCENE=  }}  
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===EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor===
===EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor===


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{{ABSTRACT_PUBMED_20346655}}
{{ABSTRACT_PUBMED_20346655}}


==About this Structure==
==About this Structure==
[[3lzb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZB OCA].  
[[3lzb]] is a 8 chain structure of [[Epidermal Growth Factor Receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZB OCA].  
 
==See Also==
*[[Epidermal Growth Factor Receptor|Epidermal Growth Factor Receptor]]


==Reference==
==Reference==
<ref group="xtra">PMID:20346655</ref><references group="xtra"/>
<ref group="xtra">PMID:020346655</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Swinger, K K.]]
[[Category: Swinger, K K.]]
[[Category: Epidermal growth factor kinase domain]]
[[Category: Multitargeted small molecule kinase inhibitor]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 00:02, 26 July 2012

File:3lzb.png

Template:STRUCTURE 3lzb

EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor

Template:ABSTRACT PUBMED 20346655

About this Structure

3lzb is a 8 chain structure of Epidermal Growth Factor Receptor with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Fidanze SD, Erickson SA, Wang GT, Mantei R, Clark RF, Sorensen BK, Bamaung NY, Kovar P, Johnson EF, Swinger KK, Stewart KD, Zhang Q, Tucker LA, Pappano WN, Wilsbacher JL, Wang J, Sheppard GS, Bell RL, Davidsen SK, Hubbard RD. Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2452-5. Epub 2010 Mar 7. PMID:20346655 doi:10.1016/j.bmcl.2010.03.015

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